FR194738 NEW
| Price | $1840 | $2390 | $3400 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-18 |
Product Details
| Product Name: FR194738 | CAS No.: 204067-52-7 |
| Purity: 99.64% | Supply Ability: 10g |
| Release date: 2025/07/18 |
Product Introduction
Bioactivity
| Name | FR194738 |
| Description | FR194738 is an inhibitor of squalene epoxidase with an IC50 of 9.8 nM in HepG2 cell homogenates. |
| In vitro | FR194738 inhibits cholesterol biosynthesis in HepG2 cells (IC50 = 2.1 nM)[1]. FR194738 concentration-dependently inhibits hamster liver microsomal squalene epoxidase activity (IC50 = 14 nM)[2]. FR194738 inhibits the incorporation of [14C]acetate in intact HepG2 cells into free cholesterol (IC50 = 4.9 nM) and cholesteryl ester (IC50 = 8.0 nM) in a concentration-dependent manner. FR194738 induces intracellular [14C]squalene accumulation and increases the incorporation of [14C]acetate into squalene[3]. |
| In vivo | FR194738 (32 and 100 mg/kg) reduces the serum levels of total, non HDL and HDL cholesterol, and triglyceride and increases HMG-CoA reductase activity by 1.3-fold at a dose of 32 mg/kg[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 200 mg/mL (420.1 mM), Sonication is recommended. |
| Keywords | squalene epoxidase, in HepG2 cell homogenates | Squalene epoxidase | FR-194738 | FR194738 | FR 194738 |
| Inhibitors Related | Dehydroacetic acid sodium | Chlorobutanol hemihydrate | 2-Butyl-1,2-benzisothiazolin-3-one | Tebuconazole | Potassium gluconate | Chitosan (MW 150000) | Methyl 2-amino-5-bromobenzoate | Veratraldehyde | Paclobutrazol | Lauryl betaine | Geraniol | Sorbic acid |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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