Fomc-cis-L-hydroxyproline-OH

Product Information

• Product Code：B201360

• English Name：Fomc-cis-L-hydroxyproline-OH

• English Alias：(2S,4S)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)-4-hydroxypyrrolidine-2-carboxylic acid

• CAS No.：189249-10-3

• Molecular Formula：C??H??NO?

• Molecular Weight：353.37

Advantages

• High Purity：Confirmed by HPLC (≥99.0%), NMR (1H, 13C), HRMS, and elemental analysis, suitable for precise modification of cis-hydroxyproline derivatives in peptide synthesis.

• Excellent Stability：Stable for 36 months at -20℃ under light-protected, sealed storage; well-soluble in common organic solvents (e.g., DMF, DCM) with degradation rate <0.5% within 6 months, ensuring synthesis reliability.

Applications

• Peptide Drug Synthesis：As an Fmoc-protected cis-hydroxyproline monomer, used in solid-phase peptide synthesis (SPPS) to construct functional peptides containing hydroxyproline, such as antifibrotic peptides and enzyme inhibitors.

• Drug Development Tool：Modulates peptide conformational stability and biological activity by introducing hydroxyproline structure in new drug development, e.g., improving serum stability or target binding capacity.

• Biochemical Research：Used to study protein-protein interactions or as a probe molecule to label biomacromolecules, regulating molecular recognition properties via hydroxyl hydrophilicity.

Background Description

Research Status

• Synthesis Process：Prepared by condensation of fluorenylmethoxycarbonyl chloride with cis-L-hydroxyproline under alkaline conditions (e.g., NaHCO?/DCM system), with optimized reaction temperature (0-5℃) and purification (reverse-phase preparative HPLC), yielding over 75%.

• Application Progress：Recent studies show that peptides containing this monomer exhibit excellent activity in treating fibrotic diseases, such as reducing collagen deposition by inhibiting TGF-β signaling; additionally, used as a linker component in ADC drugs to modify antibodies or toxin molecules via hydroxyl groups, improving conjugate stability.

• Analytical Techniques：Circular dichroism (CD) and X-ray crystallography verify β-turn structures induced in peptides, while UPLC-MS/MS monitors impurities (e.g., trans-isomers, deprotected products) during synthesis to ensure product uniformity.

WhatsAPP: +86 17320513646
E-mail: anna@molcoo.com

NOTE！

We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.
This product is intended for laboratory use only!

WhatsAPP: +86 17320513646
E-mail: anna@molcoo.com

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