PRODUCT INFORMATION

• Properties

• Spectrum

 Names

Name	1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16-pentaoxa-4-azaoctadecan-18 -oic acid
Synonym	More Synonyms

 Fmoc-NH-PEG4-CH2COOH Biological Activity

Description	Fmoc-NH-PEG4-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker
Target	Cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
References	[1]. Maggie Lu, et al. Linker-wirkstoff und antik?rper-wirkstoff-konjugat (adc) damit. EP3335734A1.

 Chemical & Physical Properties

Molecular Formula	C25H31NO8
Molecular Weight	473.51600
Exact Mass	473.20500
PSA	116.04000
LogP	2.88050
Storage condition	2-8°C

 Synthetic Route

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FmocNH-PEG4-t-b... CAS#:894427-95-3 ~65% Fmoc-NH-PEG4-CH2COOH CAS#:437655-95-3

Literature: N.V. ORGANON Patent: WO2007/42469 A2, 2007 ; Location in patent: Page/Page column 15; 16 ;

Amino-PEG4-CH2COOH CAS#:195071-49-9 9-Fluorenylmeth... CAS#:28920-43-6 ~63% Fmoc-NH-PEG4-CH2COOH CAS#:437655-95-3

Literature: Bogdan, Niculina D.; Matache, Mihaela; Meier, Veronika M.; Dobrotae, Cristian; Dumitru, Ioana; Roiban, Gheorghe D.; Funeriu, Daniel P. Chemistry - A European Journal, 2010 , vol. 16, # 7 p. 2170 - 2180

2,2'-((Oxybis(e... CAS#:112-60-7 ~% Fmoc-NH-PEG4-CH2COOH CAS#:437655-95-3

Literature: Schmidt, Florian; Rosnizeck, Ina C.; Spoerner, Michael; Kalbitzer, Hans Robert; Koenig, Burkhard Inorganica Chimica Acta, 2011 , vol. 365, # 1 p. 38 - 48

 Precursor & DownStream

Precursor  7	Previous 1/2 Next
CAS#:195071-49-9 Amino-PEG4-CH2COOH  CAS#:28920-43-6 9-Fluorenylmeth...  CAS#:112-60-7 2,2'-((Oxybis(e...  CAS#:77544-60-6 Tetraethylene g...
DownStream  0

 Synonyms

14-methylpentadecyl bromide

14-morpholin-4-yl-daunomycin

14-Morpholino-daunomycin

14-methyl-1-bromopentadecane

Pentadecane,1-bromo-14-methyl

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