Product Details
| Product Name:
Flesinoxan |
CAS No.:
98206-10-1 |
| Supply Ability:
10g |
Release date:
2025/07/19 |
Product Introduction
Bioactivity
| Name | Flesinoxan |
| Description | Flesinoxan, a hypotensive agent, is an effective, high-affinity, and selective 5-hydroxytryptamine1A receptor agonist (EC50: 24 nM). |
| In vivo | Flesinoxan functions as a partial agonist at postsynaptic and a full agonist at presynaptic 5-HT1A receptors. Its intravenous delivery inhibits the activity of both CA3 pyramidal neurons and dorsal raphe 5-HT neurons, bearing a similar antagonistic effect on 5-HT's influence on CA3 pyramidal neurons as 8-OH-DPAT. Studies of acute brain penetration revealed that nine minutes post-intravenous administration, [3H]8-OH-DPAT achieves significantly higher brain concentrations than [3H]Flesinoxan. Both Flesinoxan and 8-OH-DPAT, when administered subcutaneously, induce dose-dependent hypothermia, with Flesinoxan's effect being notably reduced by the pre-administration of pindolol, a non-selective 5-HT1A antagonist, and methysergide, a 5-HT1/2 antagonist. Comparable levels of hypothermia are observed with 3 mg/kg of Flesinoxan and 0.5 mg/kg of 8-OH-DPAT, though Flesinoxan's peak effect transpires 30 minutes later than that of 8-OH-DPAT and diminishes more gradually. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 31.25 mg/mL (75.22 mM), Sonication is recommended.
|
| Keywords | Flesinoxan | 5HTReceptor | 5-HT1A Receptor | 5HT Receptor |
| Inhibitors Related | Serotonin hydrochloride | Alverine citrate | Olanzapine | Dapoxetine hydrochloride | Clozapine N-Oxide | Mirtazapine | Amitriptyline hydrochloride | Cloperastine hydrochloride | Trazodone hydrochloride | Mianserin hydrochloride | Fluoxetine hydrochloride | Cinchonidine |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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Anhui Ruihan Technology Co., Ltd
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2023-08-21 |
United States