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Postion:Product Catalog >FICZ
FICZ
  • FICZ

FICZ NEW

Price $45 $93 $140
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2025-07-14

Product Details

Product Name: FICZ CAS No.: 172922-91-7
Purity: 98.97% Supply Ability: 10g
Release date: 2025/07/14

Product Introduction

Bioactivity

NameFICZ
DescriptionFICZ (6-Formylindolo[3,2-b]carbazole) is a potent aryl agonist for the hydrocarbon receptor (AhR, Kd: 70 pM).
Cell ResearchThe cell viability of CEH treated with FICZ or TCDD is studied with the untreated cells (used as a live cell control) and sodium hypochlorite (5%)-treated cells (used as a dead cell control). This assay is based upon the bioluminescent measurement of adenosine triphosphate (ATP) that is present in all metabolically active cells. Luciferase is utilized in this method to catalyze the formation of light from ATP and luciferin. CEH is lysed 24 h after dosing and the luminescence emitted from the ATP-dependent oxidation of luciferin is measured with a LuminoSkan Ascent luminometer [2].
In vitroFICZ (0.01 nM-1 μM) alone or in combination with 50 nM MNF induces sustained CYP1A1 activity and leads to oxidative stress and activation of apoptosis via a mitochondrial-dependent pathway. In HepG2 cells, FICZ stimulates cell growth at low concentrations but inhibits cell growth at high concentrations [1]. FICZ (10-30 μM) significantly decreases CEH viability with an estimated LC50 (95% confidence intervals) of 14 μM. FICZ shows concentration-dependent effects on EROD activity in CEH cultures, with the mean EC50 values at 3, 8, and 24 h of 0.016 nM, 0.80 nM, and 11 nM, respectively [2]. CYP1 inhibition in the presence of FICZ results in enhanced AHR activation, suggesting that FICZ accumulates in the cell when its metabolism is blocked. CYP1 enzymes play a role in regulating the biological effects of FICZ [3]. FICZ treatment increases transcript expression of CYP1A1 in a dose-dependent manner in both the parental iPSC line and the CYP1A1 targeted clone [4].
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 10 mg/mL (35.17 mM), Sonication and heating are recommended.
KeywordsInhibitor | inhibit | FICZ | ArylHydrocarbonReceptor | Aryl Hydrocarbon Receptor | aryl hydrocarbon receptor | AhR
Inhibitors RelatedCarbidopa monohydrate | Diosmin | AHR antagonist 2 | SGA360 | Benzyl butyl phthalate | Carbidopa | L-Kynurenine | Indole-3-carbinol | MeBIO | StemRegenin 1 | BAY 2416964 | PD98059
Related Compound LibrariesBioactive Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Covalent Inhibitor Library | Transcription Factor-Targeted Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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