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Postion:Product Catalog >FG 7142
FG 7142
  • FG 7142

FG 7142 NEW

Price $58 $98 $160
Package 5mg 10mg 25mg
Min. Order:
Supply Ability: 10g
Update Time: 2025-05-12

Product Details

Product Name: FG 7142 CAS No.: 78538-74-6
Purity: 98.81% Supply Ability: 10g
Release date: 2025/05/12

Product Introduction

Bioactivity

NameFG 7142
DescriptionFG 7142 (LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM). FG 7142 can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cerebral cortex. FG 7142 , a non-selectively benzodiazepine inverse agonist, has high affinity for the α1 subunit-containing GABAA receptor (Ki=91 nM).
In vitroFG-7142 has a high efficacy in modulating GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50 = 137 nM) as compared to the other α subunits.FG-7142 has affinity for those expressing the α subunit, the Ki values are 91 nM; 330 nM; 492 nM and 2.150 μM for α1, α2,α3 and α5 subunits, respectively.
In vivoFG-7142, administered via intraperitoneal injection at doses of 15 mg/kg, enhances tyrosine hydroxylase activity and dopamine turnover specifically in the medial prefrontal cortex and ventral tegmentum, without impacting mesolimbic or nigrostriatal regions. At doses between 15-30 mg/kg, it stimulates mesolimbocortical dopaminergic projections, resulting in elevated dopamine levels in the prefrontal cortex and nucleus accumbens in rats.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 30 mg/mL (133.19 mM), Sonication is recommended.
Keywordsγ-Aminobutyric acid Receptor | ZK-39106 | ZK39106 | tyrosine hydroxylase | nucleus accumben | LSU65 | LSU 65 | inverse agonist | Inhibitor | inhibit | Gamma-aminobutyric acid Receptor | GABAReceptor | GABAA receptor | GABAA | GABA Receptor | FG-7142 | FG7142 | FG 7142 | dopaminergic
Inhibitors RelatedValproic acid sodium salt | DL-Menthol | Urethane | p-Hydroxybenzaldehyde | Penicillin G sodium salt | Valproic Acid | Halothane | Chlorothymol | Piperazine citrate | Riluzole | (-)-α-Pinene | Methionine
Related Compound LibrariesPain-Related Compound Library | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Antidepressant Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Anti-Parkinson's Disease Compound Library | Neurotransmitter Receptor Compound Library | NO PAINS Compound Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | Anti-Cancer Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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