Product Details
| Product Name:
Ex26 |
CAS No.:
1233332-37-0 |
| Purity:
99.62% |
Supply Ability:
10g |
| Release date:
2025/07/26 |
Product Introduction
Bioactivity
| Name | Ex26 |
| Description | Ex26 (S1P1-IN-Ex26) is a selective and potent sphingosine 1-phosphate receptor 1 (S1P1) antagonist that disrupts SR-B1-S1PR1 interactions and inhibits S1P-S1PR1 signaling. Ex26 is used in experimental autoimmune encephalomyelitis, atherosclerosis, and gastric cancer. |
| In vitro | In U2OS cells and Chinese hamster ovary cells, Ex26 (0-10 μM; 1 hour) was confirmed as a potent and selective antagonist of S1P1 (IC50=0.93 nM)[1]. |
| In vivo | In eight-week-old male C57Bl/6J mice, S1P1-IN-Ex26 (3 mg/kg; intraperitoneal injection; once daily; 3 days) induced lymphocyte sequestration at low doses, with an ED50 of 0.06 mg/kg after 2 hours of treatment. This led to significant retention of T and B cells within the lymph nodes and significant decreases in T and B cells within the spleen[1]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | S1PReceptor | S-1P1-IN-Ex26 | S1P1INEx26 | S1P1 IN Ex26 | S1P1 | S1P Receptor |
| Inhibitors Related | Fingolimod hydrochloride | SLP9101555 | BMS-960 | LX-2931 | CYM50374 | K145 hydrochloride | ASP-4058 | Ceranib-2 | Siponimod | Fingolimod | MP-A08 | Ozanimod |
| Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Inhibitor Library | Anti-Cardiovascular Disease Compound Library | Bioactive Compounds Library Max | Fluorochemical Library | GPCR Compound Library | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States