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Postion:Product Catalog >Evocalcet Impurity21
Evocalcet Impurity21
  • Evocalcet Impurity21
  • Evocalcet Impurity21
  • Evocalcet Impurity21
  • Evocalcet Impurity21
  • Evocalcet Impurity21

Evocalcet Impurity21 NEW

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Package 10mg 50mg 100mg
Min. Order: 10mg
Supply Ability: 1000
Update Time: 2025-07-21

Product Details

Product Name: Evocalcet Impurity21 CAS No.: 870859-14-6
Min. Order: 10mg Purity: 99%+ HPLC
Supply Ability: 1000 Release date: 2025/07/21
Molecular formula: C23H24N2O2

Evocalcet Impurity21;870859-14-6

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WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com


  • Product Information

  • Product Number: E056021

  • English Name: Evocalcet Impurity 21

  • English Alias: 4-((S)-3-(((R)-1-(naphthalen-1-yl)ethyl)amino)pyrrolidin-1-yl)benzoic acid

  • CAS Number: 870859-14-6

  • Molecular Formula: C??H??N?O?

  • Molecular Weight: 360.45

  • Advantages

  • As an impurity of Evocalcet, this compound has the following advantages:

  • Well-defined and chiral-specific structure: Contains (S)-pyrrolidine, (R)-1-(naphthalen-1-yl)ethylamino, and benzoic acid groups, with chiral configurations (S/R) closely related to evocalcet. Conjugation of benzene and naphthalene rings enables unique polarity and retention, allowing accurate identification via chiral HPLC and LC-MS as a specific impurity marker;

  • High stability and traceability: Tertiary amine in pyrrolidine and carboxylic acid in benzoic acid ensure stability under neutral to weakly acidic conditions. As an intermediate derivative from chiral amine condensation in evocalcet synthesis, it directly reflects chiral center construction efficiency, improving process tracing accuracy;

  • High detection sensitivity: Strong UV absorption (270-290nm) from naphthalene-benzene conjugation, combined with characteristic mass response (m/z 361 [M+H]?), enables trace analysis via LC-MS (ppb level), compatible with calcimimetic impurity systems.

  • Applications

  • Pharmaceutical quality control: Used as an impurity reference standard to quantify Evocalcet Impurity 21 in APIs, ensuring residual chiral impurities from amine condensation meet quality standards;

  • Synthesis optimization: Optimizing condensation of (S)-pyrrolidine and (R)-1-(naphthalen-1-yl)ethylamine (catalyst, temperature) by monitoring impurity levels to enhance chiral selectivity;

  • Chiral purity assessment: Evaluating configurational purity of key chiral intermediates in evocalcet synthesis to support salt formation and purification efficiency.

  • Background Description

  • Evocalcet, a calcimimetic for secondary hyperparathyroidism, features chiral pyrrolidine and naphthylethylamino groups. During synthesis, incomplete condensation of (S)-pyrrolidine with (R)-1-(naphthalen-1-yl)ethylamine or chiral racemization may generate chiral derivatives like Evocalcet Impurity 21. Its differing calcimimetic activity and potential metabolic impacts make control critical for evocalcet quality assurance.
  • Research Status

  • Current research focuses on:

  • Analytical method validation: Developing UPLC-chiral column assays with mass detection for enantioseparation of impurity and evocalcet, achieving 0.1 ppb detection limits;

  • Chiral condensation kinetics: Studying impurity formation under varying chiral catalyst conditions to clarify stereoselectivity factors in chiral center construction;

  • Chiral stability studies: Evaluating racemization rates under accelerated storage to guide formulation design for maintaining optical purity;

  • Bioactivity comparison: Assessing differences in calcium-sensing receptor activation between impurity and evocalcet to establish scientifically based impurity limits.

We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.
This product is intended for laboratory use only!

WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com






Company Profile Introduction

1. Drug standards and drug impurity reference substances: provide more than 20,000 kinds of spot impurity reference substances, with sufficient supply and same-day delivery. We have a professional R&D team and comprehensive quality control testing to ensure product quality and reliability. 2. Customized synthesis of impurities and new molecules: Quickly respond to the customized needs of CDE impurities, stably supply impurities that have established quality standards, and provide customized synthesis services for new compounds in the research and development of innovative drugs. 3. Preparation and separation of unknown impurities: With a professional impurity preparation and separation technical team and SFC preparation and separation instruments, we can solve the problems of impurity preparation in complex projects. 4. Process development of new drug intermediates: provide the supply of new drugs and new molecular impurities, process optimization services, as well as the screening and impurity analysis of commercialization routes. 5. Peptide synthesis: Provide customized peptide synthesis services, and cover all kinds of degradation impurities and process impurities generated in the research and development of peptide drugs. At the same time, it provides comprehensive structural confirmation data and customized testing services.

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