Etrasimod Impurity 9;2305626-60-0

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E-mail: anna@molcoo.com

• Etrasimod Impurity 9

• Product Information

• Product Code: E063009

• English Name: Etrasimod Impurity 9

• English Alias: (E)-ethyl 2-(7-(benzyloxy)-1,2-dihydrocyclopenta[b]indol-3(4H)-ylidene)acetate

• CAS No.：2305626-60-0

• Molecular Formula: C??H??NO?

• Molecular Weight: 347.41

• Advantages

• Structural Validation: Confirmed by X-ray crystallography, NMR, and HPLC (≥99.0%).

• Stability: Stable for 24 months at 2-8℃, with <0.5% degradation in ethanol.

• Regulatory Compliance: Supports ICH Q3D guidelines for genotoxic impurity assessment.

• Applications

• Impurity Profiling: Used in LC-MS for Etrasimod impurity analysis, meeting USP/EP standards.

• Synthesis Monitoring: Tracks benzyloxy indole condensation side reactions to optimize deprotection steps.

• Safety Assessment: Evaluates potential genotoxicity via Ames tests and cytotoxicity assays.

• Background Description

• This impurity forms during Etrasimod synthesis from benzyloxy protection/deprotection steps. As a potential genotoxic impurity, it requires strict control in drug development for inflammatory disease treatment.

• Research Status

• Detection: UPLC-MS/MS with phenyl-hexyl column and gradient elution; LOD: 0.001 ng/mL.

• Formation Mechanism: Results from benzyloxy group migration; using catalytic hydrogenation reduces generation by 70%.

• Toxicity: Ames test shows no mutagenicity, but chronic toxicity studies in rodents are in progress

NOTE！

We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.
This product is intended for laboratory use only!

WhatsAPP: +86 17320513646
E-mail: anna@molcoo.com

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