Product Details
| Product Name:
Erucin |
CAS No.:
4430-36-8 |
| Purity:
99.97% |
Supply Ability:
10g |
| Release date:
2025/07/16 |
Product Introduction
Bioactivity
| Name | Erucin |
| Description | Erucin （1-isothiocyanato-4-methylsulfanylbutane） is a dietary isothiocyanate produced by enzymatic hydrolysis of glucoErucin with potential cancer preventive effects, involved in apoptosis and cell cycle blockade through PARP-1 cleavage, p53 and p21，Cyp450, quinone reductase (QR), glutatione transferase (GST) and other pathways. |
| In vitro | In LPS-stimulated RAW 264.7 macrophages, Erucin (2.5 and 5 μmol/L) inhibited NO and PGE? production, suppressed NF-κB activity, and reduced expression of TNF-α, IL-6, IL-1β, iNOS, and COX-2[1]. In SH-SY5Y neuroblastoma cells, Erucin (5 μM) activated the Nrf2 pathway, increased intracellular GSH levels, and protected against 6-OHDA-induced oxidative stress[2]. Erucin (30–100 μM) inhibits proliferation and migration, induces apoptosis, releases H?S, and reduces ERK1/2 phosphorylation in AsPC-1 pancreatic cancer cells[3]. |
| In vivo | In a TPA-induced mouse ear edema model, Erucin (100 and 300 nmol) significantly reduced swelling and decreased iNOS and COX-2 expression[1]. |
| Storage | store under nitrogen,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 80 mg/mL (496 mM), Sonication is recommended.
|
| Keywords | CCRIS-9056 | CCRIS9056 | CCRIS 9056 | AR1G-3839 | AR-1G-3839 | AR-1G3839 | AR1G3839 | AR-1G 3839 | AR1G 3839 | AR 1G-3839 | AR 1G3839 | AR 1G 3839 |
| Inhibitors Related | Tebuconazole | Naringin dihydrochalcone | α-Vitamin E | Apigenin | Metronidazole | Fenofibrate | Naringin | NAD+ | Naringenin | Indole-3-carbinol | Apocynin | Chlorzoxazone |
| Related Compound Libraries | Selected Plant-Sourced Compound Library | Natural Product Library for HTS |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$10.00/1kg |
|
Gihi Chemicals Co., Limited
|
2022-06-13 |
United States