Endoxifen Z-isomer hydrochloride NEW
| Price | $46 |
| Package | 2mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-16 |
Product Details
| Product Name: Endoxifen Z-isomer hydrochloride | CAS No.: 1032008-74-4 |
| Supply Ability: 10g | Release date: 2025/07/16 |
Product Introduction
Bioactivity
| Name | Endoxifen Z-isomer hydrochloride |
| Description | Endoxifen Z-isomer hydrochloride (Endoxifen HCl) is the active metabolite of Tamoxifen, which is an effective and selective estrogen receptor antagonist. |
| Cell Research | MCF7 and Ishikawa cells are grown in 10% triple charcoal-stripped serum-containing medium for 3 d. The cells are then plated at a density of 2,000 cells per well in 96-well tissue culture plates and treated as indicated every 48 h. Cell proliferation assays are conducted 8 days after the first treatment using a CellTiter-Glo Luminescent Cell Viability kit according to the manufacturer's protocol.(Only for Reference) |
| In vitro | Endoxifen shows anti-estrogenic effects, and decreases the E2-induced PR expression in MCF-7 cells. [1] Endoxifen also blocks ER-alpha transcriptional activity and inhibits estrogen-induced breast cancer cell proliferation. [2] In MCF7, HS 578T, and BT-549 cells, Endoxifen significantly inhibits cell proliferation. [3] Endoxifen also exhibits four-fold higher inhibition on PKC activity compared to tamoxifen. [4] Endoxifen inhibits the hERG current by preferentially interacting with the activated states of cloned hERG potassium channels with IC50 of 1.6 μM. [5] |
| In vivo | In vivo, Endoxifen (8 mg/kg, ) inhibits growth of MCF-7 human mammary tumor xenografts in mice, showing more potency than Tamoxifen. [3] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : <1 mg/mL Ethanol : 69 mg/mL (168.31 mM), Sonication is recommended. DMSO : 69 mg/mL (168.31 mM), Sonication is recommended. |
| Keywords | progestogenReceptor | progestogen Receptor | PotassiumChannel | Potassium Channel | KcsA | Inhibitor | inhibit | hERG | EstrogenReceptor | Estrogen Receptor/ERR | Estrogen Receptor | ERR | ER | Endoxifen Z-isomer Hydrochloride | Endoxifen Zisomer hydrochloride | Endoxifen Z-isomer | Endoxifen Z isomer hydrochloride |
| Inhibitors Related | Minoxidil sulfate | Tamoxifen | Tannic acid | Mifepristone | Estradiol | Hydrochlorothiazide | Astragaloside IV | Bisphenol B | Melatonin | Ethisterone | Chlorzoxazone | Indapamide |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $55.00/1mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2025-07-15 | |
| $65.00/1mg |
VIP1Y
|
TargetMol Chemicals Inc.
|
2025-07-17 | |
| $0.00/100mg |
VIP1Y
|
Moxin Chemicals
|
2025-02-12 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
INQUIRY