Product Details
| Product Name:
ELN-441958 |
CAS No.:
913064-47-8 |
| Purity:
98.9% |
Supply Ability:
10g |
| Release date:
2025/05/02 |
Product Introduction
Bioactivity
| Name | ELN-441958 |
| Description | ELN-441958 is a potent, neutral antagonist of the B1 receptor, inhibiting the binding of the B1 agonist ligand [3H]DAKD to IMR-90 cells with a Ki of 0.26 nM. ELN-441958 (ELN 441958) is highly selective for B1 over B2 receptors. |
| Kinase Assay | IGF-IR Peptide Autophosphorylation: One microgram of constitutively active IGF-IR kinase domain peptide isincubated +/? varying concentrations of PQ 401 in 2% DMSO in 40 mM Tris (pH 7.4), 80 μMEGTA, 0.25% 2-mercaptoethanol, 80 μM Na3VO4, 10 mM MgCl2, and 2 mM MnCl2 for 20 minutes. ATP isthen added at a final concentration of 20 μM. Autophosphorylation of the kinase domain peptide isallowed to occur for 20 minutes at 22℃. The reaction isstopped by the addition of SDS-reducing buffer and the samples are run on SDS-PAGE. Following transfer to nitrocellulose membrane, peptide autophosphorylation isdetermined by Western blotting employing an antibody against phosphotyrosine (PY20). |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 5.01 mg/mL (10 mM), Sonication is recommended.
|
| Keywords | low CNS exposure | Inhibitor | inhibit | high oral bioavailability | ELN-441958 | ELN441958 | BradykininReceptor | Bradykinin Receptor | B1 Receptor | anti-hyperalgesic |
| Inhibitors Related | Safotibant | NPC 567 acetate | [Des-Arg9]-Bradykinin acetate | B-Raf IN 14 | Lys-Bradykinin acetate(342-10-9 free base) | Anatibant 2HCl | (Hyp3)-Bradykinin acetate | MK-0686 | Sar-[D-Phe8]-des-Arg9-Bradykinin acetate | R715 TFA(185052-09-9 free base) | 5-Hydroxy-1-methylhydantoin | Lys-[Des-Arg9]Bradykinin acetate |
| Related Compound Libraries | Bioactive Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | Anti-Obesity Compound Library | Inhibitor Library | NO PAINS Compound Library | Bioactive Compounds Library Max | Preclinical Compound Library | GPCR Compound Library | Anti-Cancer Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States