Efinaconazole NEW
| Price | $5 | $4 | $2 |
| Package | 1kg | 10kg | 100kg |
| Min. Order: | 1kg |
| Supply Ability: | 100kg |
| Update Time: | 2025-06-20 |
Product Details
| Product Name: Efinaconazole | CAS No.: 164650-44-6 |
| Min. Order: 1kg | Purity: 99% |
| Supply Ability: 100kg | Release date: 2025/06/20 |
| Lead time: in stock | Packaging: bag/bottle/drum//IBC, as request |
| Delivery: By sea, by air, by express | Origin: Manufacturer, advantage products |
| COA, MSDS: Available, contact us for details | Contact : Tina |
PRODUCT INFORMATION
| Name | efinaconazole |
|---|---|
| Synonym | More Synonyms |
| Description | Efinaconazole(KP-103) is a novel triazole antifungal drug currently under development as a topical treatment for onychomycosis.IC50 value: 0.0039 ug/ml (MIC for T. mentagrophytes SM-110) [1]Target: antifungal agentin vitro: Efinaconazole was 4-fold more active than itraconazole against T. mentagrophytes SM-110 (MICs of 0.0039 and 0.016 μg/ml, respectively). Similarly, efinaconazole was 8-fold more active than clotrimazole against C. albicans ATCC 10231 (MICs of 0.00098 and 0.0078 μg/ml, respectively) [1]. In a comprehensive survey of 1,493 isolates, efinaconazole MICs against T. rubrum and T. mentagrophytes ranged from ≤ 0.002 to 0.06 μg/ml, with 90% of isolates inhibited (MIC90) at 0.008 and 0.015 μg/ml, respectively. Efinaconazole MICs against 105 C. albicans isolates ranged from ≤ 0.0005 to >0.25 μg/ml, with 50% of isolates inhibited (MIC50) by 0.001 and 0.004 μg/ml at 24 and 48 h, respectively [2].in vivo: The therapeutic efficacy of KP-103, a triazole derivative, for 10 guinea pigs with interdigital tinea pedis or tinea corporis was investigated. Topical KP-103 solution (0.25 to 1%) was dose-dependently effective in treating both dermatophytoses. A 1% KP-103-treatment rendered all infected skins culture-negative on day-2 posttreatment [3]. |
|---|---|
| Related Catalog | Signaling Pathways >> Anti-infection >> Fungal Research Areas >> Infection |
| References | [1]. Tatsumi Y, et al. Mechanism of action of efinaconazole, a novel triazole antifungal agent. Antimicrob Agents Chemother. 2013 May;57(5):2405-9. [2]. Jo Siu WJ, et al. Comparison of in vitro antifungal activities of efinaconazole and currently available antifungal agents against a variety of pathogenic fungi associated with onychomycosis. Antimicrob Agents Chemother. 2013 Apr;57(4):1610-6. [3]. Tatsum Y, et al. KP-103, a novel triazole derivative, is effective in preventing relapse and successfully treating experimental interdigital tinea pedis and tinea corporis in guinea pigs. Microbiol Immunol. 2002;46(7):425-32. |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 512.2±60.0 °C at 760 mmHg |
| Molecular Formula | C18H22F2N4O |
| Molecular Weight | 348.390 |
| Flash Point | 263.6±32.9 °C |
| Exact Mass | 348.176178 |
| PSA | 54.18000 |
| LogP | 3.46 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.590 |
| Storage condition | 2~8℃ |
| Hazard Codes | Xi |
|---|
| Efinaconazole [USAN:INN] |
| (2R,3R)-2-(2,4-Difluorophenyl)-3-(4-methylene-1-piperidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol |
| UNII-J82SB7FXWB |
| KP-103 |
| (2R,3R)-2-(2,4-difluorophenyl)-3-(4-methylidenepiperidin-1-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol |
| Efinaconazole (JAN/USAN/INN) |
| Efinaconazole |
| 1-Piperidineethanol, α-(2,4-difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-, (αR,βR)- |
| Jublia |
| Efinaconazole [INN] |
Company Profile
Our company is a high-tech enterprise specializing in chemical raw materials such as electronic materials, optoelectronic materials, semiconductor materials, UV monomers, silane catalysts, cosmetic raw materials, etc. The company integrates research and development, production, customized synthesis, and sales, and is committed to providing customers with high-quality chemical product solutions.
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Rich experience
Our products have been exported to many countries, including Germany, Spain, the United Kingdom, the United States, Australia, the Middle East, Asia, and more. We have received highly positive feedback from our clients and have established long-term friendly cooperative relationships with them.
Excellent quality, purity, and competitive price
Excellent quality is one of the cornerstones of our success. We welcome ordering samples for quality testing.
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We will arrange shipment of spot products as soon as we receive payment.
Customized products are determined based on the synthesis time of different products.
Excellent pre-sales and after-sales service
Pre sales:
We are committed to providing the most favorable quotes and detailed information about our products and company.
after-sale service:
We assist buyers in customs clearance by providing necessary documents and information.
If there is any dispute over product quality, we are committed to providing the best solution.
? Packaging:
1kg/bag, 25kg/drum, 50kg/drum, 180kg/drum, 200kg/drum, 1T/bag/drum, standard export packaging or packaging required by customers
? Shipping
? Delivery:
Within 7 days after receiving your payment
Contact information
For more details, pls contact us freely.
Contact name: Tina
Email address: Tina@fdachem.com
Mob: 86 13213167925
WhatsApp/Skype/Wechat/LINE: 86 15225627621
Company Profile Introduction
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