Product Details
| Product Name:
E1R |
CAS No.:
1301211-78-8 |
| Supply Ability:
10g |
Release date:
2025/07/16 |
Product Introduction
Bioactivity
| Name | E1R |
| Description | E1R is a positive sigma-1 receptor (Sig1R PAM) allosteric modulator. It has a cognition-enhancing activity. |
| In vitro | E1R (10?μM) does not displace the radioligand. However, in Jurkat cells, it instead increases the specific binding of a non-selective radioligand ([3H]1,3-di(2-tolyl)guanidine) for the sigma receptor by 38%. The only target for E1R (inhibition or enhancement of radioligand binding exceeding 20%) is the sigma receptor. |
| In vivo | E1R (0.1-10?mg/kg; i.p. 60?min before the training session) treatment obviously improves cognitive function in a dose-related manner in mice. E1R demonstrates efficacy against scopolamine-induced cholinergic dysfunction in mice. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 60 mg/mL (258.31 mM), Sonication is recommended.
|
| Keywords | E-1R | E1R |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
You may like
-
CAS:787623-60-3
$0.00 / 50mg
Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
United States