Droperidol NEW
| Price | $39 | $55 | $91 |
| Package | 100mg | 200mg | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-02 |
Product Details
| Product Name: Droperidol | CAS No.: 548-73-2 |
| Purity: 98.38% | Supply Ability: 10g |
| Release date: 2025/05/02 |
Product Introduction
Bioactivity
| Name | Droperidol |
| Description | Droperidol (Dehydrobenzperidol) is a Dopamine-2 Receptor Antagonist. The mechanism of action of droperidol is as a Dopamine D2 Antagonist. |
| In vitro | Droperidol has a dual effect on repolarization, prolonging the development of EADs and the subsequent triggering of activity in rabbit Purkinje fibers at low concentrations. In rabbit Purkinje fibers stimulated with 60 pulses/min, 0.01 mM-0.3 mM Droperidol increased action potential duration (APD) in a dose-dependent manner without altering other parameters.1 mM-3 mM Droperidol resulted in a reversal of the prolongation effect in rabbit Purkinje fibers.10 mM- 30 mM Droperidol produced a shortening of the APD at 50% repolarization, accompanied by significant reductions in Vmax, action potential amplitude, and resting membrane potential in rabbit Purkinje fibers. A single dose of 3 mg/kg Droperidol not only dose-dependently reduced activity and rearing frequency in the open-field experiment, but also reduced the Apomorphine effect in rats.Droperidol (3 mg/kg, long-term administration) induced significant tolerance to all activity parameters recorded in the rat open field. |
| In vivo | Droperidol has been shown to block potassium efflux from the myocardium of isolated animal ventricular myocytes, resulting in a dose-dependent delay in repolarization.Droperidol also induces early depolarization of Purkinje fibers in isolated animals.Droperidol produces mild alpha-adrenergic blockade and peripheral vasodilation. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 65 mg/mL (171.31 mM), Sonication is recommended. |
| Keywords | NSC-169874 | NSC169874 | Inhibitor | inhibit | Droperidol | DopamineReceptor | Dopamine Receptor | Dopamine | D2 |
| Inhibitors Related | Olanzapine | Clozapine N-Oxide | Mirtazapine | Octopamine hydrochloride | Benserazide hydrochloride | L-DOPA | Octodrine | Citicoline | Phenothiazine | Oxolinic acid | Mianserin hydrochloride | Doxepin hydrochloride |
| Related Compound Libraries | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | CNS-Penetrant Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library | FDA-Approved Drug Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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