午夜插插,噜噜噜影院,啪啪伊人网,欧美熟夫,景甜吻戏视频,男人强操性感蕾丝美女视频在线网站,日本美女跳舞视频

Welcome to chemicalbook!
+1 (818) 612-2111
RFQ
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

RFQ
skype
MY Account
Top
Postion:Product Catalog >Dotinurad Impurity
Dotinurad Impurity
  • Dotinurad Impurity
  • Dotinurad Impurity
  • Dotinurad Impurity
  • Dotinurad Impurity
  • Dotinurad Impurity

Dotinurad Impurity NEW

Price Get Latest Price
Package 10mg 50mg 100mg
Min. Order: 10mg
Supply Ability: 1000
Update Time: 2025-06-18

Product Details

Product Name: Dotinurad Impurity CAS No.: 428458-98-4
Min. Order: 10mg Purity: 99%+ HPLC
Supply Ability: 1000 Release date: 2025/06/18

Dotinurad Impurity;428458-98-4

Article illustration

WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com

Product Information

  • Product Code:D081070

  • English Name:Dotinurad Impurity 70

  • English Alias:3,5-dichloro-4-methoxy-N-phenylbenzamide

  • CAS No.:428458-98-4

  • Molecular Formula:C??H??Cl?NO?

  • Molecular Weight:296.15

Advantages

  • High-Purity Reference Standard:Confirmed by HPLC (≥99.0%), NMR (1H, 13C), HRMS, and elemental analysis, suitable for Dotinurad impurity analysis and quality control.

  • Stability Assurance:Stable for 36 months at -20℃ under light-protected, sealed storage; degradation rate <0.3% in methanol-acetonitrile mixture within 6 months.

Applications

  • Quality Control Testing:Used for UPLC-MS/MS detection of Impurity 70 in Dotinurad API and formulations, controlling content to meet ICH Q3A standards (single impurity limit ≤0.1%).

  • Process Optimization Research:Monitors impurity formation during Dotinurad synthesis, reducing generation by >30% by adjusting amidation temperature (e.g., 50-60℃) and reaction time.

  • Method Validation:Serves as a standard for developing impurity detection methods, verifying UPLC resolution (≥3.0) and LOD (0.01 ng/mL).

Background Description

Dotinurad, a uric acid transporter 1 (URAT1) inhibitor, is used for treating hyperuricemia and gout. Impurity 70, as a process-related impurity in Dotinurad synthesis, may originate from side reactions between chlorobenzoyl chloride and aniline. Its chlorine atoms, methoxy, and benzamide groups may affect drug solubility, stability, and target binding. With stricter requirements for gout drug impurities, studying this impurity is crucial for ensuring drug quality.

Research Status

  • Detection Technology:UPLC-MS/MS with C18 column (1.7μm) and 0.1% formic acid-acetonitrile gradient elution achieves separation within 6 minutes, with LOD of 0.005 ng/mL for trace impurity analysis.

  • Formation Mechanism:Formed by condensation of 3,5-dichloro-4-methoxybenzoyl chloride with aniline under alkaline conditions (e.g., triethylamine/dichloromethane system); optimizing base dosage and reaction temperature inhibits side reactions.

  • Safety Evaluation:In vitro cytotoxicity shows IC?? of 186.5 μM against HEK293 cells (Dotinurad IC??=8.7 μM), with lower toxicity than the main drug but requiring strict content control. Long-term stability testing is ongoing to monitor degradation under different humidity, light, and temperature conditions.

NOTE!

We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.
This product is intended for laboratory use only!

WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com


NEW IN STOCK!

The Molcoo Laboratory added drug impurity reference standards, including Baricitinib, Piperazine, Benzylpenicillin, Tranilast and multiple N-Nitroso drug impurities! Now available for immediate delivery! 


Company Profile Introduction

1. Drug standards and drug impurity reference substances: provide more than 20,000 kinds of spot impurity reference substances, with sufficient supply and same-day delivery. We have a professional R&D team and comprehensive quality control testing to ensure product quality and reliability. 2. Customized synthesis of impurities and new molecules: Quickly respond to the customized needs of CDE impurities, stably supply impurities that have established quality standards, and provide customized synthesis services for new compounds in the research and development of innovative drugs. 3. Preparation and separation of unknown impurities: With a professional impurity preparation and separation technical team and SFC preparation and separation instruments, we can solve the problems of impurity preparation in complex projects. 4. Process development of new drug intermediates: provide the supply of new drugs and new molecular impurities, process optimization services, as well as the screening and impurity analysis of commercialization routes. 5. Peptide synthesis: Provide customized peptide synthesis services, and cover all kinds of degradation impurities and process impurities generated in the research and development of peptide drugs. At the same time, it provides comprehensive structural confirmation data and customized testing services.

You may like

Recommended supplier

Product name Price   Suppliers Update time
$0.00/1g
VIP1Y
Shanghai Wish Pharma Co., Ltd
2025-07-25
$0.00/10mg
VIP2Y
ShenZhen H&D Pharmaceutical Technology Co., LTD
2025-03-18
$0.00/5kg
VIP1Y
Guangzhou Tosun Pharmaceutical Ltd
2024-12-27
INQUIRY