DOTA-?NHS-?ester NEW
| Price | $41 | $98 | $143 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-30 |
Product Details
| Product Name: DOTA-?NHS-?ester | CAS No.: 170908-81-3 |
| Supply Ability: 10g | Release date: 2025/05/30 |
Product Introduction
Bioactivity
| Name | DOTA-?NHS-?ester |
| Description | DOTA-NHS-ester is a linker for affibody molecules with applications in small animal PET, SPECT, and CT. It can be used to label radiotherapeutic agents or imaging probes for tumor detection. |
| In vitro | METHODS: The binding kinetics of hIMB1636 to Trop2 antigen were measured by biofilm interferometry (BLI). Western blotting was used to screen Trop2 expression in pancreatic cancer cell lines. Flow cytometry and cell immunofluorescence were used to evaluate the binding ability of hIMB1636 and Trop2 on the cell surface. hIMB1636 was conjugated with p-SCN-Bn-NOTA (NOTA) and DOTA-NHS-ester (DOTA) for 64Cu and 177Lu radiolabeling. RESULTS According to the BLI results, hIMB1636 had a strong binding affinity to Trop2. According to the results of Western blotting, flow cytometry, and cell immunofluorescence, the T3M-4 cell line showed the strongest expression of Trop2 and the specific binding ability of hIMB1636. The radiochemical purity of 64Cu-NOTA-hIMB1636 and 177Lu-DOTA-hIMB1636 exceeded 95%. [2] |
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (99.70 mM), Sonication is recommended. |
| Keywords | tumor | tomography | SPECT | SKOV3 | single-photon | radiometal | positron | PET | Inhibitor | inhibit | HSA | emission | DOTA-NHS-ester | DOTA?NHS?ester | DOTA ?NHS ?ester | cancer | Antibody-drug conjugates linkers | ADCLinker | ADC Linkers | ADC Linker |
| Inhibitors Related | N-Boc-PEG5-bromide | Succinic anhydride | DSS Crosslinker | Val-cit-PAB-OH | Fmoc-8-amino-3,6-dioxaoctanoic acid | Fmoc-Gly-Gly-OH | SMCC | Boc-NH-PEG4-CH2COOH | EMCS | DSP Crosslinker | DSG Crosslinker | FMoc-Val-Cit-PAB-PNP |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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