Product Details
| Product Name:
Dopropidil |
CAS No.:
79700-61-1 |
| Supply Ability:
10g |
Release date:
2025/07/17 |
Product Introduction
Bioactivity
| Name | Dopropidil |
| Description | Dopropidil is a new anti-angina pectoris calcium regulator, which has intracellular calcium antagonist activity and anti-ischemic effects in various predicted animal models. |
| In vitro | In the calcium-free medium (IC50 = 30.0 uM), dopredil can inhibit caffeine-induced contraction of rabbit renal arteries. Dopredil inhibits norepinephrine (NE)-induced responses with IC50 of 2.7 and 29.8 uM, respectively. At 3 μM and 10 μM, dopredil significantly reduced the maximum increase in diastolic pressure caused by veratrine (IC50 = 2.8 μM). |
| In vivo | Dopamine (1 and 2.5 mg/kg) dose-dependently reduced electrical (ST segment elevation), biochemical (lactate production and potassium release) and mechanical (myocardial segment contractility loss) disturbances caused by ischemia in anesthetized dogs. Intraduodenal administration of dopredil (50 mg/kg) can significantly reduce tachycardia caused by isoproterenol. This effect is evident between 15 and 120 minutes after application of the compound, indicating rapid absorption and long duration of action. In awake dogs, doprodil (12-14 mg/kg p.o.) can reduce the resting heart rate by about 10 beats/minute. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | Dopropidil | CalciumChannel | Calcium Channel | Calcium |
| Inhibitors Related | Nisoldipine | Nimodipine | Diltiazem hydrochloride | Levetiracetam | L-Ascorbic acid | Lanthanum(III) chloride heptahydrate | Ethyl cinnamate | 1-Octanol | 2-Nitrobenzoic acid | 1,2,4-Trihydroxybenzene | Methyl homoveratrate | Otilonium bromide |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$1980.00/50mg |
VIP1Y
|
TargetMol Chemicals Inc.
|
2025-07-16 |
United States