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Postion:Product Catalog >Dobutamine EP Impurity C(Hydrobromide)
Dobutamine EP Impurity C(Hydrobromide)
  • Dobutamine EP Impurity C(Hydrobromide)
  • Dobutamine EP Impurity C(Hydrobromide)
  • Dobutamine EP Impurity C(Hydrobromide)
  • Dobutamine EP Impurity C(Hydrobromide)
  • Dobutamine EP Impurity C(Hydrobromide)

Dobutamine EP Impurity C(Hydrobromide) NEW

Price Get Latest Price
Package 10mg 50mg 100mg
Min. Order: 10mg
Supply Ability: 1000
Update Time: 2025-07-17

Product Details

Product Name: Dobutamine EP Impurity C(Hydrobromide) Min. Order: 10mg
Purity: 99%+ HPLC Supply Ability: 1000
Release date: 2025/07/17
Molecular formula: C21H29NO3.HBr

Dobutamine EP Impurity C(Hydrobromide)

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WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com
.

  • Product Information

  • Product Number: D044002B

  • English Name: Dobutamine EP Impurity C(Hydrobromide)

  • English Alias: N-(3,4-dimethoxyphenethyl)-4-(4-methoxyphenyl)butan-2-amine hydrobromide

  • CAS Number: None

  • Molecular Formula: C??H??NO?·HBr

  • Molecular Weight: 424.37(343.46 + 80.91)

  • Advantages

  • As an EP impurity reference standard (hydrobromide form) for dobutamine, this compound has the following advantages:

  • Well-defined structure and stable salt form, enabling analysis of by-product formation mechanisms during dobutamine synthesis, such as benzene ring substitution and amination reactions, to optimize processes and control impurity generation;

  • As a salt-form reference standard containing polymethoxybenzene rings and amino groups, it provides a stable quantitative standard for HPLC, LC-MS, and other detection methods, improving method accuracy;

  • The hydrobromide form enhances water solubility, facilitating simulation of impurity behavior in physiological environments during formulation stability studies.

  • Applications

  • Drug Development: Used as an impurity reference standard to identify and quantify Impurity C in dobutamine preparations, evaluating the purity of APIs and formulations;

  • Quality Control: Acting as a standard substance to validate the sensitivity and specificity of detection methods (e.g., HPLC or LC-MS), ensuring compliance with EP pharmacopoeia requirements;

  • Stability Studies: Investigating the degradation behavior of hydrobromide under acidic/alkaline conditions to evaluate its impact on dobutamine injection stability.

  • Background Description

  • Dobutamine is a β-adrenergic receptor agonist used for treating heart failure. During its synthesis, incomplete methoxylation reactions or abnormal amino substitution positions easily generate impurities containing polymethoxybenzene rings. As an impurity controlled by the EP pharmacopoeia, research on this hydrobromide impurity is a key part of dobutamine quality control, especially in injectable formulations where its content must be strictly controlled to ensure medication safety.
  • Research Status

  • Current research focuses on:

  • Detection Method Optimization: Establishing trace detection methods using UPLC-MS/MS technology, leveraging the ionization characteristics of hydrobromide to enhance mass spectrometry response sensitivity;

  • Synthesis Process Improvement: Reducing by-product generation by optimizing the catalyst (such as palladium carbon) and reaction temperature of methoxylation reactions;

  • Salt Form Stability: Studying the hygroscopicity and degradation pathways of hydrobromide under high temperature and humidity conditions to provide data for storage conditions;

  • Toxicological Evaluation: Evaluating the potential impact of this impurity on cardiac muscle cells through in vitro cytotoxicity experiments to assist in setting safe limits

This product is intended for laboratory use only!

WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com








Company Profile Introduction

1. Drug standards and drug impurity reference substances: provide more than 20,000 kinds of spot impurity reference substances, with sufficient supply and same-day delivery. We have a professional R&D team and comprehensive quality control testing to ensure product quality and reliability. 2. Customized synthesis of impurities and new molecules: Quickly respond to the customized needs of CDE impurities, stably supply impurities that have established quality standards, and provide customized synthesis services for new compounds in the research and development of innovative drugs. 3. Preparation and separation of unknown impurities: With a professional impurity preparation and separation technical team and SFC preparation and separation instruments, we can solve the problems of impurity preparation in complex projects. 4. Process development of new drug intermediates: provide the supply of new drugs and new molecular impurities, process optimization services, as well as the screening and impurity analysis of commercialization routes. 5. Peptide synthesis: Provide customized peptide synthesis services, and cover all kinds of degradation impurities and process impurities generated in the research and development of peptide drugs. At the same time, it provides comprehensive structural confirmation data and customized testing services.

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