Product Details
| Product Name:
Diphyllin |
CAS No.:
22055-22-7 |
| Purity:
99.91% |
Supply Ability:
10g |
| Release date:
2025/07/27 |
Product Introduction
Bioactivity
| Name | Diphyllin |
| Description | Diphyllin could be characterized as a new V-ATPase inhibitor in treating gastric cancer and inhibiting the phosphorylation of LRP6 in Wnt/β-catenin signaling. |
| In vitro | The in vitro inhibitory effects of these compounds were evaluated on the production of nitric oxide (NO) and cytokines (tumor necrosis factor (TNF)-alpha and interleukin (IL)-12), from LPS/IFN-gamma activated murine peritoneal macrophages. The results indicated that the 50% inhibition concentration (IC(50)) values of NO production from activated peritoneal macrophages by compounds 1-4 were 100, 25, 12.5 and 50 microM, respectively. In parallel, these dilutions were approximately inhibited in a similar manner to that observed for cytokines (TNF-alpha, and IL-12) production. On the other hand, at 100 microM concentration compounds 3 and 4 showed 50% inhibition of NO production from peritoneal macrophages that had been pre-activated with LPS/IFN-gamma for 24h, whereas compounds 1 and 2 inhibited only about 20 and 10%, respectively. |
| Storage | keep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 3.8 mg/mL (9.99 mM), Sonication is recommended.
|
| Keywords | Wnt/β-catenin | VSV | virus | Vesicular stomatitis virus (VSV) | Vacuolar type H+-ATPase | Protonpump | Proton Pump | Proton pump | lignan | Inhibitor | inhibit | InfluenzaVirus | Influenza Virus | influenza | Human immunodeficiency virus | HIVProtease | HIV-1 | HIV Protease | HIV | Diphyllin | cytotoxicity | c-Myc | ATPase | arylnaphthalene | antiviral |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Emtricitabine | Valproic acid sodium salt | Dextran sulfate sodium salt (MW 4500-5500) | Lamivudine | Nitazoxanide | Valproic Acid | Curcumin | Naringenin | Decanedioic acid | Salcomine |
| Related Compound Libraries | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Selected Plant-Sourced Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library | Inhibitor Library | Anti-infective Natural Product Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$9.80/1KG |
VIP6Y
|
Career Henan Chemical Co
|
2020-01-09 |
United States