Dicyclomine NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-04-28 |
Product Details
| Product Name: Dicyclomine | CAS No.: 77-19-0 |
| Supply Ability: 10g | Release date: 2025/04/28 |
Product Introduction
Bioactivity
| Name | Dicyclomine |
| Description | Dicyclomine (Dicycloverine) is a potent, orally active antagonist of muscarinic cholinergic receptors, specifically M1 and M2 subtypes, with Ki values of 5.1 nM and 54.6 nM in brush-border and basal plasma membranes, respectively [1] [2]. As an antispasmodic agent, it relieves smooth muscle spasm of the gastrointestinal tract in vivo. |
| In vivo | Intraperitoneal injections of Dicyclomine (Dicycloverine), administered daily at doses of 2.0, 4.0, and 8.0 mg/kg for a week, significantly impaired cognitive performance and memory in C57Bl/6 mice, with a pronounced effect observed in the paired-associates learning (PAL) task. Notably, at the highest dosage (8 mg/kg), Dicyclomine exacerbated cognitive impairments across all measurements. Furthermore, 3xTg-AD mice treated with Dicyclomine displayed worse memory impairments than NonTg mice treated similarly. Lower doses also led to behavioral impairments in spatial tasks, suggesting that Dicyclomine's detrimental effects on cognition result from its actions beyond the hippocampus. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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