Desfesoterodine NEW
| Price | $60 | $147 | $228 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-26 |
Product Details
| Product Name: Desfesoterodine | CAS No.: 207679-81-0 |
| Purity: 100% | Supply Ability: 10g |
| Release date: 2025/07/26 |
Product Introduction
Bioactivity
| Name | Desfesoterodine |
| Description | Desfesoterodine (5-HMT) is a new muscarinic receptor antagonist with Kb of 0.84 nM. |
| In vitro | Desfesoterodine is a major pharmacologically active metabolite of tolterodine. Desfesoterodine produces a competitive and concentration-dependent inhibition of carbachol-induced contraction of guinea-pig isolated urinary bladder strips. Desfesoterodine antagotizes muscarinic receptors with a pA2 of 9.1. Desfesoterodine causes a concentration-dependent inhibition of (-)3 H-QNB binding in homogenates of guinea-pig urinary bladder, parotid gland, heart and cerebral cortex. [1] Desfesoterodine has a similar pharmacological profile with tolterodine. [2] Intravenous infusion of Desfesoterodine produces a dose-dependent inhibition of the intravesical volume-induced urinary bladder contraction measured as the micturition pressure. [3] |
| In vivo | Desfesoterodine is significantly more potent at inhibiting acetylcholine-induced urinary bladder contraction than electrically induced salivation in the anaesthetised cat (ID50 15 and 40 nmol/kg, respectively. Desfesoterodine is three times more potent at the urinary bladder compared to the salivary gland. [1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : 63 mg/mL (184.49 mM), Sonication is recommended. DMSO : 65 mg/mL (190.34 mM), Sonication is recommended. H2O : < 1 mg/mL (insoluble or slightly soluble) |
| Keywords | Tolterodine | receptor | PNU-200583 | PNU200577 | PNU 200577 | pA2 | Muscarinic acetylcholine receptor | muscarinic | metabolite | mAChR | Inhibitor | inhibit | Fesoterodine | Desfesoterodine | 5-Hydroxymethyl Tolterodine |
| Inhibitors Related | Adiphenine hydrochloride | Nanofin | Forskolin | Pilocarpine Hydrochloride | Clozapine N-Oxide | Pilocarpine nitrate | Urethane | Ribavirin | D-Menthol | Amitriptyline hydrochloride | Choline chloride | Propoxur |
| Related Compound Libraries | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Neuronal Signaling Compound Library | Anti-Alzheimer's Disease Compound Library | Membrane Protein-targeted Compound Library | Neurotransmitter Receptor Compound Library | Inhibitor Library | Bioactive Compounds Library Max | Preclinical Compound Library | Human Metabolite Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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