DB1976 dihydrochloride NEW
| Price | $390 | $1330 | $1740 |
| Package | 5mg | 25mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-16 |
Product Details
| Product Name: DB1976 dihydrochloride | CAS No.: 2369663-93-2 |
| Purity: 99.08% | Supply Ability: 10g |
| Release date: 2025/07/16 |
Product Introduction
Bioactivity
| Name | DB1976 dihydrochloride |
| Description | DB1976 dihydrochloride (DB1976 2HCl) , a transcription factor PU.1 inhibitor with potential anti-inflammatory activity, slowed down inflammation and fibrosis and improved glucose homeostasis and dyslipidemia in mice in in vivo experiments.DB1976 dihydrochloride promotes apoptosis and may be used in studies of metabolic dysfunction and non-alcoholic steatohepatitis. |
| In vitro | DB1976 dihydrochloride , a classic heterocyclic dication with strong affinity and selectivity for AT-rich sequences commonly found in cognate DNA binding sites for PU.1[3], inhibits PU.1-dependent transactivation of the reporter in a dose-dependent manner with an IC50 value of 2.4 μM in PU.1-negative HEK293 cells[2]. Treatment with DB1976 dihydrochloride leads to a profound decrease in the growth of PU.1 URE–/– AML cells (IC50 of 105 μM), while exhibiting little effect on normal hematopoietic cells at similar concentrations (IC50 of 334 μM)[2].Furthermore,DB1976 dihydrochloride treatment results in a 1.6-fold increase in apoptotic cells in murine PU.1 URE–/– AML cells, with similar effects observed in human MOLM13 cells[3].In addition, DB1976 dihydrochloride treatment causes a significant decrease in the number of viable cells (primary human AML cells) (mean decrease of 81%) and clonogenic capacity (mean decrease of 36%) compared to vehicle-treated cells. The apoptotic cell fraction increases on average by 1.5-fold with DB1976 dihydrochloride[2]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 20 mg/mL (38.44 mM), Sonication is recommended. H2O : 10 mg/mL (19.22 mM), Sonication is recommended. |
| Keywords | NF-κB | NFκB | NF-kB | NFkB | Apoptosis |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Flubendazole | Cysteamine hydrochloride | Dextran sulfate sodium salt (MW 4500-5500) | Sodium 4-phenylbutyrate | L-Ascorbic acid | L-Glutamic acid | Tributyrin | N,N-Dimethylacetamide | L-Ascorbic acid sodium salt | Alginic acid |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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