Dasotraline hydrochloride NEW
| Price | $41 | $66 | $98 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-15 |
Product Details
| Product Name: Dasotraline hydrochloride | CAS No.: 675126-08-6 |
| Purity: 98.92% | Supply Ability: 10g |
| Release date: 2025/07/15 |
Product Introduction
Bioactivity
| Name | Dasotraline hydrochloride |
| Description | Dasotraline hydrochloride (SEP-225289 hydrochloride) is a triple reuptake inhibitor that inhibits dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively. |
| In vivo | Acute administration of dasotraline decreases the spontaneous firing rate of LC NE (norepinephrine), VTA DA (dopamine), and DR 5-HT (serotonin) neurons in a dose-dependent manner by activating α2, D2, and 5-HT1A autoreceptors, respectively. Primarily, dasotraline significantly reduces the firing rate of LC NE neurons, while moderately impacting VTA DA and DR 5-HT neuronal activity. Concurrently, SEP-225289, known as (dasotraline), demonstrates equal potency in inhibiting both 5-HT and NE transporters, effectively extending the time for a 50% recuperation of firing activity in dorsal hippocampus CA3 pyramidal neurons following the inhibition induced by the microiontophoretic application of 5-HT and NE. Moreover, the average occupancies of dopamine and serotonin transporters by SEP-225289 escalate with dose increments, showing transporter occupancies of approximately 33%±11% and 2%±13% for 8 mg, 44%±4% and 9%±10% for 12 mg, and 49%±7% and 14%±15% for 16 mg, for dopamine and serotonin transporters, respectively. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 31 mg/mL (94.32 mM), Sonication is recommended. |
| Keywords | SLC6A4 | SLC6A3 | SERT | SerotoninTransporter | Serotonin Transporter | SEP-225289 Hydrochloride | SEP225289 Hydrochloride | SEP-225289 | SEP225289 | SEP 225289 Hydrochloride | SEP 225289 | Norepinephrine (NE) | Inhibitor | inhibit | DopamineReceptor | Dopamine Transporter | Dopamine Receptor | Dopamine | DAT | Dasotraline hydrochloride | Dasotraline Hydrochloride | Dasotraline | 5-HTT | 5HTReceptor | 5HT Receptor | 5-HT |
| Inhibitors Related | Alverine citrate | Dapoxetine hydrochloride | Clozapine N-Oxide | Octopamine hydrochloride | D-Menthol | Citicoline | Amitriptyline hydrochloride | Oxolinic acid | Trazodone hydrochloride | Mianserin hydrochloride | Fluoxetine hydrochloride | Cinchonidine |
| Related Compound Libraries | Bioactive Compound Library | Pain-Related Compound Library | Anti-Neurodegenerative Disease Compound Library | Membrane Protein-targeted Compound Library | Anti-Parkinson's Disease Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Clinical Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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