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Postion:Product Catalog >API>Anesthetic Agents>Skeletal muscle relaxants>Dantrolene Sodium
Dantrolene Sodium
  • Dantrolene Sodium
  • Dantrolene Sodium

Dantrolene Sodium NEW

Price $9 $6 $3
Package 1KG 5KG 25KG
Min. Order: 0.01KG
Supply Ability: g-kg-tons, free sample is available
Update Time: 2025-06-20

Product Details

Product Name: Dantrolene Sodium CAS No.: 14663-23-1
Min. Order: 0.01KG Purity: 99%
Supply Ability: g-kg-tons, free sample is available Release date: 2025/06/20
Lead time: In stock, ready for shipment Packaging: 1kg,5kg,25kgs,200kgs;bulk
Delivery: By express, by air, by sea Origin: Manufacturer, advantage product
COA, MSDS: Available, contact us for details Note: Hot sales

Dantrolene Sodium

Modify Date: 2024-01-01 19:41:05


Article illustration
Dantrolene Sodium structure
Common NameDantrolene Sodium
CAS Number14663-23-1Molecular Weight336.235
DensityN/ABoiling Point85°C 4mm
Molecular FormulaC14H9N4NaO5Melting PointN/A
MSDSChineseUSAFlash Point283.1oC








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 Use of Dantrolene Sodium


Dantrolene sodium is a inhibitor of calcium channel proteins, inhibiting the release of Ca2+ from the sarcoplasm. Dantrolene sodium is a skeletal muscle relaxant which acts by blocking muscle contraction beyond the neuromuscular junction.

 Names

Namedantrolene sodium (anhydrous)
SynonymMore Synonyms

 Dantrolene Sodium Biological Activity

DescriptionDantrolene sodium is a inhibitor of calcium channel proteins, inhibiting the release of Ca2+ from the sarcoplasm. Dantrolene sodium is a skeletal muscle relaxant which acts by blocking muscle contraction beyond the neuromuscular junction.
Related Catalog
Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel
Research Areas >> Others

 Chemical & Physical Properties

Boiling Point85°C 4mm
Molecular FormulaC14H9N4NaO5
Molecular Weight336.235
Flash Point283.1oC
Exact Mass336.047058
PSA127.05000
LogP1.71410
Storage conditionStore at RT

 MSDS

Dantrolene Sodium MSDS(Chinese)

 Toxicological Information

CHEMICAL IDENTIFICATION

  • RTECS NUMBER :

  • MU3875000

  • CHEMICAL NAME :

  • Hydantoin, 1-((5-(p-nitrophenyl)furfurylidene)amino)-, sodium salt

  • CAS REGISTRY NUMBER :

  • 14663-23-1

  • LAST UPDATED :

  • 199612

  • DATA ITEMS CITED :

  • 19

  • MOLECULAR FORMULA :

  • C14-H9-N4-O5.Na

  • MOLECULAR WEIGHT :

  • 336.26

  • WISWESSER LINE NOTATION :

  • T5OJ BR DNW& E1UN- AT5NVMV EHJ &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Human

  • DOSE/DURATION :

  • 320 mg/kg

  • TOXIC EFFECTS :

  • Behavioral - somnolence (general depressed activity) Behavioral - anorexia (human) Gastrointestinal - nausea or vomiting

  • REFERENCE :

  • JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 231,662,1975

  • TYPE OF TEST :

  • LDLo - Lowest published lethal dose

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Human - woman

  • DOSE/DURATION :

  • 600 mg/kg

  • TOXIC EFFECTS :

  • Gastrointestinal - nausea or vomiting Gastrointestinal - other changes Liver - hepatitis (hepatocellular necrosis), diffuse

  • REFERENCE :

  • NYSJAM New York State Journal of Medicine. (Medical Soc. of the State of New York, POB 5405, Lake Success, NY 11042) V.1- 1901- Volume(issue)/page/year: 77,1759,1977

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 7432 mg/kg

  • TOXIC EFFECTS :

  • Behavioral - muscle weakness Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression

  • REFERENCE :

  • KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 11,3065,1977

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 413 mg/kg

  • TOXIC EFFECTS :

  • Behavioral - muscle weakness Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression

  • REFERENCE :

  • KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 11,3065,1977

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Subcutaneous

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • >16 gm/kg

  • TOXIC EFFECTS :

  • Lungs, Thorax, or Respiration - dyspnea Blood - changes in spleen

  • REFERENCE :

  • KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 11,3065,1977

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Intravenous

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • >50 mg/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • REFERENCE :

  • KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 11,3065,1977

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • 1188 mg/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • REFERENCE :

  • JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 69,327,1980

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • 534 mg/kg

  • TOXIC EFFECTS :

  • Behavioral - muscle weakness Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression

  • REFERENCE :

  • KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 11,3065,1977

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Subcutaneous

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • >16 gm/kg

  • TOXIC EFFECTS :

  • Lungs, Thorax, or Respiration - dyspnea Blood - changes in spleen

  • REFERENCE :

  • KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 11,3065,1977

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Intravenous

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • >50 mg/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • REFERENCE :

  • KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 11,3065,1977

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Mammal - dog

  • DOSE/DURATION :

  • >10550 mg/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • REFERENCE :

  • IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 25,815,1994 ** OTHER MULTIPLE DOSE TOXICITY DATA **

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 70 gm/kg/5W-C

  • TOXIC EFFECTS :

  • Liver - other changes Blood - changes in spleen Nutritional and Gross Metabolic - weight loss or decreased weight gain

  • REFERENCE :

  • KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 11,2691,1977

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 90 gm/kg/26W-C

  • TOXIC EFFECTS :

  • Kidney, Ureter, Bladder - other changes Blood - changes in spleen Nutritional and Gross Metabolic - weight loss or decreased weight gain

  • REFERENCE :

  • KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 11,2691,1977

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 488 mg/kg/60D-I

  • TOXIC EFFECTS :

  • Behavioral - muscle weakness Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases

  • REFERENCE :

  • MSCREJ Medical Science Research. (Elsevier Applied Science Pub. Ltd., Crown House, Linton Rd., Barking, Essex IG11 8JU, UK) V.15- 1987- Volume(issue)/page/year: 21,475,1993

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Mammal - dog

  • DOSE/DURATION :

  • 21900 mg/kg/1Y-I

  • TOXIC EFFECTS :

  • Kidney, Ureter, Bladder - other changes in urine composition Nutritional and Gross Metabolic - weight loss or decreased weight gain

  • REFERENCE :

  • YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 32,655,1981 ** REPRODUCTIVE DATA **

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Intravenous

  • DOSE :

  • 3143 ug/kg

  • SEX/DURATION :

  • female 39 week(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Maternal Effects - uterus, cervix, vagina

  • REFERENCE :

  • AACRAT Anesthesia and Analgesia (New York). (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.36- 1957- Volume(issue)/page/year: 66,269,1987

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • DOSE :

  • 500 mg/kg

  • SEX/DURATION :

  • female 14 day(s) pre-mating female 7-17 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

  • REFERENCE :

  • KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 11,2218,1977

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • DOSE :

  • 260 mg/kg

  • SEX/DURATION :

  • female 6-18 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Specific Developmental Abnormalities - musculoskeletal system

  • REFERENCE :

  • KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 11,2212,1977 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5530 No. of Facilities: 35 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1371 (estimated) No. of Female Employees: 673 (estimated)

 Safety Information

Safety PhrasesS22-S24/25
RIDADRNONH for all modes of transport
WGK Germany2
RTECSMU3875000
HS Code2934999090





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Our company is a high-tech enterprise specializing in chemical raw materials such as electronic materials, optoelectronic materials, semiconductor materials, UV monomers, silane catalysts, cosmetic raw materials, etc. The company integrates research and development, production, customized synthesis, and sales, and is committed to providing customers with high-quality chemical product solutions. With our agile custom synthesis capabilities and responsive supply chain system, our products have gained widespread adoption across Asian markets including Japan, South Korea, Singapore, and Malaysia, while also expanding deeply into Europe and the Americas. We have forged long-term strategic partnerships with numerous leading global enterprises in the sector. "Driving value through technology and earning trust through service" is our core mission. Looking ahead, we will continue to focus on technological breakthroughs and green innovation in new materials, collaborating with partners to build a high-quality industrial ecosystem and provide globally competitive solutions with greater foresight.

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