Curcumin NEW
| Price | $50 | $88 |
| Package | 100mg | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-30 |
Product Details
| Product Name: Curcumin | CAS No.: 458-37-7 |
| Purity: 95.00% | Supply Ability: 10g |
| Release date: 2025/07/30 |
Product Introduction
Bioactivity
| Name | Curcumin |
| Description | Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity. Curcumin has a wide range of pharmacological activities such as antitumor, anti-inflammatory and antioxidant. |
| Cell Research | 1×104 B16-R cells are cultivated as monolayer culture for 12 hr. They were then incubated in 200 μL of RPMI, 10% FBS containing curcumin at final concentrations from 1–100 μM in 96-multiwell plates for 24-48 hr. After these incubations, cells are washed twice in PBS and 500 μl of fresh culture medium containing MTT (0.3 mg/mL) are added for colorimetric assay. (Only for Reference) |
| In vitro | METHODS: Retinoblastoma cells SO-Rb50 and Y79 were treated with Curcumin (10-50 μM) for 24 h. Cell viability was measured by CCK-8. RESULTS: Curcumin dose-dependently and significantly decreased the cell viability of SO-Rb50 and Y79 cells, with IC50s of 38.4 μM and 34.8 μM, respectively.[1] METHODS: Mouse colon cancer cells MC38 were treated with Curcumin (5-50 μM) for 48 h. Apoptosis was detected by Flow Cytometry. RESULTS: Curcumin dose-dependently induced apoptosis in MC38 cells. [2] METHODS: Human pancreatic cancer cells PANC1 were treated with Curcumin (10-80 μg/mL) for 24 h. The autophagy marker LC3 was detected by Immunofluorescence. RESULTS: The highest expression level of punctate autophagosomes was found in 40 μg/mL Curcumin-treated cells. [3] |
| In vivo | METHODS: To detect the anti-tumor activity in vivo, Curcumin (100-200 mg/kg) was administered by gavage every three days for three weeks to C57BL/6J mice bearing mouse colon cancer tumor MC38. RESULTS: The average tumor volume and tumor weight of mice in the Curcumin treatment group were significantly reduced, and the tumor volume and tumor weight of the 200 mg/kg treatment group were also significantly lower than those of the 100 mg/kg treatment group. [2] METHODS: To detect anti-tumor activity in vivo, Curcumin (25-50 mg/kg) was injected intraperitoneally into BALB/c mice bearing Ehrlich ascites tumor EAT once daily for ten days. RESULTS: The number of EAT cells in the peripheral tissues of the Curcumin 50 mg/kg group was significantly less than that of the tumor control group. [4] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 60 mg/mL (162.88 mM), Sonication is recommended. Ethanol : 1.8 mg/mL (4.89 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 6 mg/mL (16.29 mM), Solution. |
| Keywords | p300 histone acetylatransferase | Natural Yellow-3 | Natural Yellow3 | Mitophagy | Mitochondrial Autophagy | KEAP1-Nrf2 | Keap1-Nrf2 | Inhibitor | inhibit | InfluenzaVirus | Influenza Virus | HistoneAcetyltransferase | Histone Acetyltransferase | HATs | HAT | Ferroptosis | EpigeneticReaderDomain | Epigenetic Reader Domain | Curcumin | Autophagy |
| Inhibitors Related | Stavudine | Aceglutamide | Cysteamine hydrochloride | Sodium 4-phenylbutyrate | Acetaminophen | Hydroxychloroquine | Guanidine hydrochloride | L-Glutamic acid | Paeonol | Naringin | Alginic acid | Gefitinib |
| Related Compound Libraries | Polyphenolic Natural Product Library | Failed Clinical Trials Compound Library | Traditional Chinese Medicine Monomer Library | Anti-Cancer Clinical Compound Library | Natural Product Library | Antiparasitic Natural Product Library | Inhibitor Library | Natural Product Library for HTS | Immunology/Inflammation Compound Library | Bitter Compound library | Anti-Aging Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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