Clodronate disodium is the first generation bisphosphonates for the treatment of osteoporosis, and bisphosphonates (BPs) are a new class of drugs used for various bone diseases and calcium metabolic diseases. It can specifically bind to hydroxyapatite in bone, inhibit osteoclast activity, and thus inhibit bone resorption. Used for the treatment of osteoporosis, deformable osteoarthritis, hypercalcemia and bone pain caused by malignant tumor bone metastasis, etc