Product Details
| Product Name:
Cipepofol |
CAS No.:
1637741-58-2 |
| Purity:
99.77% |
Supply Ability:
10g |
| Release date:
2025/07/27 |
Product Introduction
Bioactivity
| Name | Cipepofol |
| Description | Cipepofol (HSK3486) is a GABAA receptor agonist with sedative properties and protective effects in a variety of cardiovascular diseases.Cipepofol activates the Sirtuin1 (Sirt1)/Nrf2 pathway and induces apoptosis in cardiomyocytes, and can be used to study myocardial infarction, myocardial ischemia/reperfusion injury, and octopus pot syndrome. |
| In vitro | Cipepofol (5 μM; administered before ISO injury; for 6 hours) can attenuate ISO-induced apoptosis in cultured cardiomyocytes in vitro[2]. |
| In vivo | In eighty male C57BL/6 mice (20-24 g, 8-10 weeks old), Cipepofol (100 μl; administered into the abdomen of mice 1 hour before ISO injection) was able to attenuate the increase in serum CK-MB, LDH, and cTnT levels induced by ISO (100 mg/kg; subcutaneous injection; for 2 consecutive days) to create experimental myocardial infarction. Additionally, Cipepofol significantly improved ISO-induced left ventricular systolic and diastolic dysfunction[2]. |
| Storage | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 80 mg/mL (391.56 mM), Sonication is recommended.
|
| Keywords | GABAReceptor | GABAA | GABA Receptor | Cipepofol | Apoptosis |
| Inhibitors Related | Stavudine | Cysteamine hydrochloride | Acetylcysteine | Sodium 4-phenylbutyrate | p-Hydroxybenzaldehyde | Urethane | L-Ascorbic acid | L-Glutamic acid | Tributyrin | Valproic Acid | L-Ascorbic acid sodium salt | Alginic acid |
| Related Compound Libraries | Apoptosis Compound Library | Pain-Related Compound Library | Bioactive Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Drug Repurposing Compound Library | Neuroprotective Compound Library | Bioactive Compounds Library Max | Ion Channel Targeted Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States