Chromomycin A3 NEW
| Price | Get Latest Price | ||
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-06-30 |
Product Details
| Product Name: Chromomycin A3 | CAS No.: 7059-24-7 |
| Supply Ability: 10g | Release date: 2025/06/30 |
Product Introduction
Bioactivity
| Name | Chromomycin A3 |
| Description | Chromomycin A3 is an antibiotic produced by Streptomyces sp that binds to gc-rich DNA sequences in the presence of divalent cations and inhibits DNA replication and transcription; it is also used as a fluorescent DNA stain and assay; and it has anticancer activity against diseases such as Hodgkin's, lung adenocarcinomas, melanomas, and breast cancer. |
| In vitro | Chromomycin A3 showed strong antiproliferative effects in human pancreatic cancer cells AsPC-1, MIA PaCa-2, and BxPC-3 (IC??: 2.01, 1.34, and 1.15 nM, respectively; 72 h treatment), and induced apoptosis at 5 nM with increased cleaved caspase-3 and PARP[1]. |
| In vivo | In a MIA PaCa-2 xenograft model, intraperitoneal injection of Chromomycin A3 (0.5 mg/kg, once daily for 14 days) reduced tumor volume by over 60% without notable toxicity; tumor tissues showed reduced Ki-67 and increased cleaved caspase-3[1]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 80.00 mg/mL (67.61 mM), Sonication is recommended. |
| Keywords | Chromomycin A-3 | Chromomycin A3 |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Flubendazole | Cysteamine hydrochloride | L-Glutamic acid monosodium salt monohydrate | Myricetin | Sodium 4-phenylbutyrate | L-Ascorbic acid | L-Glutamic acid | Tributyrin | L-Ascorbic acid sodium salt | Alginic acid |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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