Product Details
| Product Name:
Certolizumab pegol |
CAS No.:
428863-50-7 |
| Purity:
98.2% (SDS-PAGE); 99.1% (SEC-HPLC) |
Supply Ability:
10g |
| Release date:
2025/07/28 |
Product Introduction
Bioactivity
| Name | Certolizumab pegol |
| Description | Certolizumab pegol (Certolizumab) is a polyethylene glycolated and humanized anti-TNF-α monoclonal antibody for the study of autoimmune diseases such as rheumatoid arthritis (RA), psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA). |
| In vitro | Certolizumab pegol was able to neutralize soluble TNFα with an IC90 value of 3 ng/mL.Certolizumab pegol was able to completely inhibit IL-1β production by human monocytes in response to LPS stimulation after treatment at concentrations ranging from 0-100 μg/mL for 1 h. Certolizumab pegol does not mediate complement-dependent cytotoxicity (CDC) or antibody-dependent cell-mediated cytotoxicity (ADCC). In addition, Certolizumab pegol does not induce apoptosis in activated human monocytes or peripheral blood lymphocytes (PBL), nor does it cause degranulation or disruption of cell membrane integrity in polymorphonuclear cells. [1] |
| In vivo | Acute edematous pancreatitis was induced in healthy Wistar Albino male rats by intraperitoneal injection of 80 μg/kg of Cerulein (20 μg/kg each time for 4 doses, 1 hour apart). Subsequently, a single intraperitoneal injection of 10 μg Certolizumab pegol significantly reduced serum levels of amylase, lipase and lactate dehydrogenase. Histopathologic examination showed significant reductions in edema, hemorrhage, parenchymal necrosis, and infiltration scores. In addition, malondialdehyde, myeloperoxidase, TNF-α and caspase-3 activities were significantly reduced. [2] |
| Storage | store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | TNF-α |
| Inhibitors Related | Acetylcysteine | Isosteviol | Taxifolin | Acefylline | Glucosamine | Thalidomide | Apremilast | Pomalidomide | Lenalidomide | Fisetin | Linalool | Taurocholic acid |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
-
CAS:880-52-4
$29.00 / 10mg
-
CAS:370586-05-3
$59.00 / 1mg
-
CAS:13463-41-7
$35.00 / 500mg
Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$397.00/1mg |
VIP1Y
|
TargetMol Chemicals Inc.
|
2025-04-29 |
United States