Product Details
| Product Name:
CC0651 |
CAS No.:
1319207-44-7 |
| Supply Ability:
10g |
Release date:
2025/07/17 |
Product Introduction
Bioactivity
| Name | CC0651 |
| Description | CC0651 is an allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme that potently inhibits the ubiquitination of p27Kip1 (IC50: 1.72 μM). |
| In vitro | CC0651 functions by stabilizing a weak interaction between ubiquitin and the E2 donor ubiquitin-binding site. It completely inhibits polyubiquitin chain assembly, reduces the formation of free triubiquitin, and minimally affects hCdc34 monoubiquitin production, with no impact on diubiquitin production [1]. CC0651 significantly impairs the initiation rate of ubiquitin chains on substrates by SCFCdc4, as indicated by the monoubiquitination of Sic1 by K0 ubiquitin. Interestingly, CC0651 enhances the formation of ubiquitin dimers and monoubiquitinated hCdc34, consistent with the accumulation of the hCdc34 conjugate in cells treated with its ester derivative. A quantitative SCF ubiquitination assay using a β-Catenin substrate peptide determined an IC50 value of 18±1 μM for CC0651 inhibition, aligning with concentrations effective in NMR and TR-FRET assays [2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 56 mg/mL (126.61 mM), Sonication is recommended.
|
| Keywords | p27Kip1 ubiquitination | CC-0651 | CC0651 | CC 0651 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Suppliers |
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$3100.00/100mg |
VIP1Y
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TargetMol Chemicals Inc.
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2024-10-22 |
United States