CB1R Allosteric modulator 4 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-21 |
Product Details
| Product Name: CB1R Allosteric modulator 4 | CAS No.: 2633686-53-8 |
| Supply Ability: 10g | Release date: 2025/07/21 |
Product Introduction
Bioactivity
| Name | CB1R Allosteric modulator 4 |
| Description | CB1R Allosteric modulator 4 is an effective and positive modulator of cannabinoid type-1 (CB1R), exhibiting significant biological activity. This compound inhibits the production of cAMP and demonstrates strong β-arrestin-2 recruitment [1]. |
| In vitro | CB1R, the most prevalent G-protein coupled receptor (GPCR) in the CNS, plays a vital role in various physiological processes, including neurotransmission and energy metabolism [1]. The CB1R Allosteric Modulator 4 (compound 66b) demonstrated significant pharmacological activity across different concentrations and durations. At concentrations ranging from 0.10 nM to 10μM for 30 minutes, the compound effectively inhibited forskolin-stimulated cAMP production in CHO hCB1R cells, with an EC50 value of 0.05 μM [1]. Furthermore, at the same concentration range but over a 90-minute period, it facilitated β-arrestin-2 recruitment in hCB1R-CHO-K1 cells, evidenced by an EC50 value of 0.163 μM [1]. Additionally, when applied at concentrations between 1.6 and 200 μM for 2 hours, the modulator not only maintained good biological activity but also exhibited enhanced aqueous solubility, reaching a solubility limit of 3.13 μM [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
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