CB-6644 NEW
| Price | $228 | $579 | $829 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-16 |
Product Details
| Product Name: CB-6644 | CAS No.: 2316817-88-4 |
| Purity: 100% | Supply Ability: 10g |
| Release date: 2025/07/16 |
Product Introduction
Bioactivity
| Name | CB-6644 |
| Description | CB-6644 is a small molecule inhibitor of the ATPase activity of the RUVBL1/2 complex. It specifically interacts with RUVBL1/2 in cancer cells and blocks the ATPase activity of RUVBL1/2 with a half-maximal inhibitory concentration (IC50) of 15 nM[1]. |
| In vitro | METHODS: HCT116, NCI-1975, and HT29 cells were treated with CB-6644 (100nM-500nM) and allowed to form colonies within 3 weeks. RESULTS CB-6644 was able to effectively kill cells with an EC50 range of 41 ~ 785 nM. [1] |
| In vivo | METHODS: Plasma concentrations and tumor growth were measured in nude female mice or after a single intravenous dose (0.5 mg/kg) of CB-6644. RESULTS CB-6644 can significantly inhibit tumor growth and has little effect on body weight. [1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 1.43 mg/mL (2.5 mM), Sonication is recommended. |
| Keywords | RUVBL1/2 | Inhibitor | inhibit | CB-6644 | CB6644 | CB 6644 |
| Related Compound Libraries | Bioactive Compound Library | Inhibitor Library | Bioactive Compounds Library Max | Fluorochemical Library | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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