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Postion:Product Catalog >CAY10591
CAY10591
  • CAY10591

CAY10591 NEW

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Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2025-07-23

Product Details

Product Name: CAY10591 CAS No.: 839699-72-8
Supply Ability: 10g Release date: 2025/07/23

Product Introduction

Bioactivity

NameCAY10591
DescriptionSirtuins (SIRTs) represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs). Human SIRT1 is the homolog of yeast silent information regulator 2 (Sir2) and has been shown to regulate the activity of the p53 tumor suppressor and inhibit apoptosis. Small molecule activators of SIRT1, such as resveratrol, extend lifespan in yeast and C. elegans in a manner that resembles caloric restriction. CAY10591 has been identified as an activator of the enzyme SIRT1. This compound increases fluorescence by 233% in a SIRT1 activity assay. [Activator activity was defined as the percentage of signal increase relative to signal window in the following formula: 100 x (Sample - Signallow)/(Signalhigh - Signallow)]. CAY10591 suppresses TNF-α in a dose-dependent manner. In THP-1 cells, TNF-α levels decreased from 325 pg/ml (control) to 104 and 53 pg/ml with 20 and 60 µM CAY10591, respectively. This activator also has a significant dose-dependent effect on fat mobilization in differentiated adipocytes, which would indicate the potential of SIRT1 activators for anti-obesity or anti-diabetic purposes.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationDMSO : 20 mg/mL (54.43 mM), Sonication is recommended.
DMF:PBS (pH 7.2) (1:1) : 0.5 mg/mL (1.36 mM), Sonication is recommended.
DMF : 30 mg/mL (81.65 mM), Sonication is recommended.
Ethanol : 1 mg/mL (2.72 mM), Sonication is recommended.
KeywordsCAY 10591 | CAY-10591

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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