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Postion:Product Catalog >Cabazitaxel Impurity
Cabazitaxel Impurity
  • Cabazitaxel Impurity
  • Cabazitaxel Impurity
  • Cabazitaxel Impurity
  • Cabazitaxel Impurity
  • Cabazitaxel Impurity

Cabazitaxel Impurity NEW

Price Get Latest Price
Package 10mg 50mg 100mg
Min. Order: 10mg
Supply Ability: 1000
Update Time: 2025-07-17

Product Details

Product Name: Cabazitaxel Impurity CAS No.: 1714967-27-7
Min. Order: 10mg Purity: 99%+ HPLC
Supply Ability: 1000 Release date: 2025/07/17
Molecular formula: C45H57NO14

Cabazitaxel Impurity;1714967-27-7

Article illustration

WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com
.

  • Product Information

  • Product Number: C100008

  • English Name: Cabazitaxel Impurity 8

  • English Alias: (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9-(((2S,3R)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate

  • CAS Number: 1714967-27-7

  • Molecular Formula: C??H??NO??

  • Molecular Weight: 835.93

  • Advantages

  • As an impurity reference standard for cabazitaxel, this compound has significant advantages:

  • Well-defined and Stable Structure: Its complex and precise chemical structure, along with good stability, helps in deeply analyzing the by-product formation mechanisms of multiple reactions during cabazitaxel synthesis, such as acylation, hydroxyl protection and deprotection, thus optimizing the production process.

  • Reliable Detection Standard: Containing multiple functional groups like ester, hydroxyl, amino groups and a special fused - ring structure, it can provide an accurate standard for detection methods such as HPLC and LC-MS, greatly improving the separation and quantification accuracy of complex impurities of cabazitaxel.

  • Facilitating Quality Research: It can assist in studying the influence of impurity structure on drug stability, efficacy and toxicological properties, providing key evidence for formulating scientific and reasonable impurity control strategies to ensure drug quality and safety.

  • Applications

  • Drug Development: During the research and development of cabazitaxel and its formulations, it is used as an impurity reference standard to identify and quantify Cabazitaxel Impurity 8, accurately evaluating the purity of APIs and formulations to ensure drug quality meets the standards.

  • Quality Control: Serving as a standard substance, it is used to verify the sensitivity and specificity of detection methods such as HPLC and LC-MS, strictly controlling the content of this impurity during production to meet pharmacopoeia and relevant regulatory requirements.

  • Stability Studies: Investigating the degradation behavior of this impurity under different environmental conditions such as light, high temperature and high humidity, evaluating its impact on the stability of cabazitaxel formulations, and providing strong data support for determining reasonable storage conditions and shelf life.

  • Background Description

  • Cabazitaxel is a taxane-based anticancer drug commonly used in the treatment of malignant tumors such as prostate cancer, exerting its anticancer effect by inhibiting microtubule depolymerization. During its synthesis, due to multiple complex organic reactions, such as side-chain attachment and functional group modification, if reaction conditions are not properly controlled, raw materials remain, or side reactions occur, complex impurities like Cabazitaxel Impurity 8 are likely to be generated. The presence of these impurities may affect drug safety, effectiveness and bioavailability. Therefore, the research and strict control of cabazitaxel impurities are key links to ensure drug quality and clinical medication safety.
  • Research Status

  • Currently, research on Cabazitaxel Impurity 8 mainly focuses on the following aspects:

  • Detection Method Optimization: Using advanced technologies such as ultra-high-performance liquid chromatography - tandem mass spectrometry (UPLC-MS/MS) and high-resolution mass spectrometry (HRMS), continuously developing and improving highly sensitive and selective detection methods to achieve trace detection of this impurity.

  • Synthesis Process Improvement: Deeply studying the formation pathway of this impurity, and developing efficient synthesis processes to reduce impurity generation by optimizing reaction conditions (such as reaction temperature, time, catalyst selection), improving raw material ratios and reaction sequences.

  • Toxicological Evaluation: Using in vitro cytotoxicity experiments, animal models and other means to comprehensively evaluate the potential toxicity of this impurity, providing sufficient data support for scientifically formulating reasonable impurity limit standards.

  • Stability Research: Systematically studying the stability of this impurity under the influence of different environmental factors, analyzing its interactions with other components in cabazitaxel formulations, and further improving the drug quality control system

This product is intended for laboratory use only!

WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com








Company Profile Introduction

1. Drug standards and drug impurity reference substances: provide more than 20,000 kinds of spot impurity reference substances, with sufficient supply and same-day delivery. We have a professional R&D team and comprehensive quality control testing to ensure product quality and reliability. 2. Customized synthesis of impurities and new molecules: Quickly respond to the customized needs of CDE impurities, stably supply impurities that have established quality standards, and provide customized synthesis services for new compounds in the research and development of innovative drugs. 3. Preparation and separation of unknown impurities: With a professional impurity preparation and separation technical team and SFC preparation and separation instruments, we can solve the problems of impurity preparation in complex projects. 4. Process development of new drug intermediates: provide the supply of new drugs and new molecular impurities, process optimization services, as well as the screening and impurity analysis of commercialization routes. 5. Peptide synthesis: Provide customized peptide synthesis services, and cover all kinds of degradation impurities and process impurities generated in the research and development of peptide drugs. At the same time, it provides comprehensive structural confirmation data and customized testing services.

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