Product Details
| Product Name:
BMS493 |
CAS No.:
215030-90-3 |
| Purity:
100% |
Supply Ability:
10g |
| Release date:
2025/05/23 |
Product Introduction
Bioactivity
| Name | BMS493 |
| Description | BMS493 is an inverse agonist of the pan-retinoic acid receptor (RAR) that inhibits retinoic acid-induced differentiation, enhances the interaction of nuclear co-inhibitors with RARs, attenuates RA signaling, potentiates TPP-induced toxicity, and inhibits the increase in phospholipase A2 activity. |
| In vitro | Cells treated with BMS 493 (100 nM; 6 days) showed a twofold increase in the number of ALDHhi cells available for transplantation compared to untreated controls. Newly expanded ALDHhi cells exhibited increased numbers of CD34 and CD133-positive cells, along with a reduction in CD38 expression[1]. |
| In vivo | In contrast to freshly isolated ALDHhi cells, 6-day expansion with or without BMS 493 generated progeny that were unable to reduce hyperglycemia after iPan transplantation into STZ-treated NOD/SCID mice[1]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 30 mg/mL (74.16 mM), Sonication is recommended.
|
| Keywords | RetinoidReceptor | Retinoid Receptor | RAR | phospholipase A2 | BMS493 | BMS 493 |
| Inhibitors Related | Neomycin sulfate | Isotretinoin | Adapalene | Oxybenzone | 1-Naphthaleneacetic acid potassium salt | trans-Benzylideneacetone | Benzylideneacetone | (E/Z)-Polydatin | Indomethacin | 1-Naphthaleneacetic acid | Darapladib | Lansoprazole |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$0.00/1removed |
VIP3Y
|
TargetMol Chemicals Inc.
|
2025-05-23 |
United States