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Postion:Product Catalog >BMS-1166
BMS-1166
  • BMS-1166

BMS-1166 NEW

Price $68 $157 $237
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2025-05-19

Product Details

Product Name: BMS-1166 CAS No.: 1818314-88-3
Purity: 99.22% Supply Ability: 10g
Release date: 2025/05/19

Product Introduction

Bioactivity

NameBMS-1166
DescriptionBMS-1166 is a potent inhibitor of the PD-1/PD-L1 interaction.
Kinase AssayPurified proteins in 10 mM Tris (pH 8.0) containing 20 mM NaCl, were concentrated to 5 mg/ml, mixed with the inhibitor in 1:3 molar ratio (protein:compound) and clarified by centrifugation at 15 000 × g for 10 min. Supernatant was used for screening using a sitting-drop vapor diffusion method. Diffraction-quality crystals were obtained at room temperature from 0.1 M Tris pH 8.5 containing 0.2 M magnesium chloride and 30% (w/v) PEG 4000 for the hPD-L1/BMS-1001 complex and from 0.01 M Tris pH 8.4 containing 0.28 M sodium chloride and 27% (w/v) PEG 4000 for hPD-L1/BMS-1166 complex.
In vitroBMS-1166 alleviate the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes. Moreover, the compounds were effective in attenuating the inhibitory effect of the cell surface-associated PD-L1.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 125 mg/mL (194.97 mM), Sonication is recommended.
KeywordsPD-L1 | PDL1 | PD-1/PD-L1 | PD1/PDL1 | PD-1 | PD1 | interaction | Inhibitor | inhibit | immune | dimerization | checkpoint | cell | BMS-1166 | BMS1166 | BMS 1166 | activation
Inhibitors RelatedLSD1-IN-24 | PD-1/PD-L1-IN-9 | Sulfamethoxypyridazine | BMS-202 | PD-1-IN-22 | BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride | IMMH 010 maleate | Camrelizumab | LSD1-IN-27 | BMS-1 | Anti-Mouse PD-1 Antibody (RMP1-14) | PD-L1-IN-3
Related Compound LibrariesApoptosis Compound Library | Bioactive Compound Library | Anti-Breast Cancer Compound Library | Hematonosis Compound Library | Inhibitor Library | Immuno-Oncology Compound Library | PPI Inhibitor Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Covalent Inhibitor Library | Cell Cycle Compound Library | Anti-Liver Cancer Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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