BI 689648 NEW
| Price | $985 | $1280 | $1940 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-17 |
Product Details
| Product Name: BI 689648 | CAS No.: 1633009-87-6 |
| Supply Ability: 10g | Release date: 2025/07/17 |
Product Introduction
Bioactivity
| Name | BI 689648 |
| Description | BI 689648 is a highly selective inhibitor of aldosterone synthase(CYP11B1 and CYP11B2 with IC50s of 310 and 2.1 nM, respectively). |
| In vitro | In comparison with FADs and LCI699, BI 689648 exhibits remarkable selectivity in vitro, demonstrating an IC50 value of 2.1 nM for CYP11B2 and a selectivity factor of 149 over CYP11B1. Meanwhile, FAD286 presents a comparable IC50 value for CYP11B2 at 2.5 nM, but its higher efficacy against CYP11B1 (94 nM) yields a relatively lower selectivity factor of 38, which is about fourfold lesser than that of BI 689648[1]. |
| In vivo | After oral administration in cyno monkeys, BI 689648 (5 mg/kg) achieves a peak plasma concentration of ~500 nM. BI 689648 minimally impacts 11-DC, but only at very high plasma concentrations (~10 μM)[1]. For BI 689648 (aldosterone EC50 = 2 nM), significant changes in 11-DOC are observed at plasma concentrations >2000 nM or >1000-fold its aldosterone EC50, whereas FAD286 exhibits a window of ~100-fold. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 30 mg/mL (100.56 mM), Sonication and heating are recommended. |
| Keywords | CYP11B2 | CYP11B1 | BI-689648 | BI689648 | BI 689648 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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