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Postion:Product Catalog >Belumosudil mesylate
Belumosudil mesylate
  • Belumosudil mesylate

Belumosudil mesylate NEW

Price $68
Package 5mg
Min. Order:
Supply Ability: 10g
Update Time: 2025-07-21

Product Details

Product Name: Belumosudil mesylate CAS No.: 2109704-99-4
Purity: 98.73% Supply Ability: 10g
Release date: 2025/07/21

Product Introduction

Bioactivity

NameBelumosudil mesylate
DescriptionBelumosudil mesylate (KD025 mesylate) is a selective and highly efficient ROCK2 inhibitor with antifibrotic activity. It inhibits ROCK1 and can be used in chronic graft-versus-host disease research.
In vitroBelumosudil mesylate is a selective inhibitor of ROCK2, with IC50s of 105 nM and 24 μM for ROCK2 and ROCK1, respectively.[1] 40 μM Belumosudil mesylate significantly down-regulated the levels of Tsp-1 and CTGF mRNA in pulmonary artery smooth muscle cells (PASMC). [1]
In vivoIntraperitoneal injection of 100, 200, or 300 mg/kg Belumosudil mesylate dose-dependently reduced infarct volume after transient middle cerebral artery occlusion. Belumosudil mesylate was at least as effective in aged, diabetic, or female mice as in normal adult male mice. [2]
Storagekeep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationH2O : 1 mg/mL (1.82 mM), Sonication and heating are recommended.
DMSO : 20 mg/mL (36.46 mM), Sonication and heating are recommended.
KeywordsSLx-2119mesylate | KD-025 Mesylate
Inhibitors RelatedSB-747651A Dihydrochloride | GSK180736A | Fasudil | SAR407899 hydrochloride | RKI-1447 | Belumosudil | Fasudil hydrochloride | Y-27632 dihydrochloride | Tofacitinib | Y-27632 | ROCK-IN-5 | Thiazovivin

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, USA
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