Befiradol hydrochloride NEW
| Price | $152 | $378 | $553 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-04-28 |
Product Details
| Product Name: Befiradol hydrochloride | CAS No.: 2436760-81-3 |
| Purity: 99.1% | Supply Ability: 10g |
| Release date: 2025/04/28 |
Product Introduction
Bioactivity
| Name | Befiradol hydrochloride |
| Description | Befiradol hydrochloride (NLX-112 hydrochloride) is a selective 5-hydroxytryptamine 1A (5-HT1A) receptor agonist with anxiolytic properties and inhibits mutant ATXN3 aggregation. |
| In vivo | Befiradol hydrochloride (F13640 hydrochloride; NLX-112 hydrochloride) decreases the activity of dorsal raphe serotonergic neurons when administered intravenously at doses ranging from 0.2 to 18.2 μg/kg, with an effective dose (ED50) of 0.69 μg/kg, i.v. At the same dosage range, it enhances the firing rate of 80% of the medial prefrontal cortex (mPFC) pyramidal neurons, with an ED50 of 0.62 μg/kg, i.v.[1] Befiradol hydrochloride (0.04-0.63 mg/kg; i.p.) dose-dependently decreases extracellular 5-HT in the hippocampus and mPFC.[1] Befiradol hydrochloride (0.01-2.5 mg/kg; i.p.) dose-dependently increases extracellular DA in mPFC, an effect dependent on the activation of postsynaptic 5-HT1A receptors in mPFC. Local perfusion of Befiradol hydrochloride in mPFC (1-1000 μM) also increases extracellular DA in a concentration-dependent manner.[1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 43.03 mg/mL (100 mM), Sonication is recommended. |
| Keywords | NLX-112 Hydrochloride | NLX112 Hydrochloride | NLX 112 Hydrochloride | F-13640 Hydrochloride | F13640 Hydrochloride | F 13640 Hydrochloride | Befiradol Hydrochloride | 5HTReceptor | 5-HT1A | 5HT Receptor |
| Inhibitors Related | Alverine citrate | Olanzapine | Dapoxetine hydrochloride | Clozapine N-Oxide | Mirtazapine | D-Menthol | Amitriptyline hydrochloride | Cloperastine hydrochloride | Trazodone hydrochloride | Mianserin hydrochloride | Fluoxetine hydrochloride | Cinchonidine |
| Related Compound Libraries | Bioactive Compound Library | Pain-Related Compound Library | Anti-Neurodegenerative Disease Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Neurotransmitter Receptor Compound Library | Drug Repurposing Compound Library | Angiogenesis related Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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