Bay 41-4109 NEW
| Price | $386 | $2270 | $2980 |
| Package | 2mg | 25mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-18 |
Product Details
| Product Name: Bay 41-4109 | CAS No.: 298708-81-3 |
| Supply Ability: 10g | Release date: 2025/07/18 |
Product Introduction
Bioactivity
| Name | Bay 41-4109 |
| Description | BAY 41-4109 is a potent inhibitor of human hepatitis B virus (HBV) with an IC50 of 53 nM. |
| In vitro | BAY 41-4109 effectively accelerates and alters the direction of capsid assembly in vitro, demonstrating potent inhibitory effects on both HBV DNA release and cytoplasmic HBcAg levels, with IC50 values of 32.6 and 132 nM in HepG2.2.15 cells, respectively. Its inhibitory action on HBV DNA and HBcAg is dose-dependent, underscoring that its anti-HBV properties hinge on the rate at which HBcAg is inhibited. Additionally, BAY 41-4109 can stabilize preformed capsids, achieving a stabilization ratio of one inhibitor molecule per two dimers. |
| In vivo | BAY 41-4109 effectively suppresses virus production in vivo through a mechanism focusing on the viral capsid[2]. It dose-dependently decreases viral DNA in both the liver and plasma, showing efficacy on par with 3TC, and it diminishes hepatitis B virus core antigen (HBcAg) in the livers of HBV-transgenic mice. Pharmacokinetic evaluations in mice reveal quick absorption, 30% bioavailability, and dose-proportional plasma concentrations, reaching approximately 60% in rats and dogs[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 100 mg/mL (252.68 mM), Sonication is recommended. |
| Keywords | HBV | Bay 41-4109 | Bay 414109 | Bay 41 4109 |
| Inhibitors Related | Doxorubicin hydrochloride | Osthole | RO8191 | Cetylpyridinium Chloride | Tenofovir Disoproxil Fumarate | Thiamine hydrochloride | 4,5-Dicaffeoylquinic acid | 4-Hydroxyacetophenone | Telbivudine | Tenofovir | Osalmid | Bifendate |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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