Baicalein NEW
| Price | $30 | $36 |
| Package | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-29 |
Product Details
| Product Name: Baicalein | CAS No.: 491-67-8 |
| Purity: 97.25% | Supply Ability: 10g |
| Release date: 2025/05/29 |
Product Introduction
Bioactivity
| Name | Baicalein |
| Description | Baicalein (5,6,7-Trihydroxyflavone) is a xanthine oxidase inhibitor. |
| Cell Research | MTT assay is conducted to evaluate the effect of baicalein on proliferation of breast cancer cells. MDA-MB-231 cells are routinely digested, collected, and then seeded in 96-well plates at a density of 8×103 cells/well. After incubation for 12-24 hours, cells are treated with 0, 20, 40, 60, 80, 100, and 120 μM baicalein according to their experimental grouping and then incubated at 37°C for 24, 48, and 72 hours[3]. |
| In vitro | Baicalein effectively inhibits T cell proliferation and cytokine secretion in response to mitogens in vitro. It has been observed that pre-treatment with baicalein markedly reduces both Con A or anti-CD3/CD28 mAb-induced cell proliferation and cytokine release at a concentration of 25 μM. Additionally, baicalein initiates NF-κB DNA binding while concurrently inhibiting nuclear thioredoxin activity. Furthermore, baicalein hampers the proliferation, migration, and invasion of MDA-MB-231 cells in both a time- and dose-dependent manner, significantly lowering SATB1 expression in these cells. It also diminishes the expression of Wnt1 and β-catenin proteins, along with the transcription of Wnt/β-catenin-regulated genes. |
| In vivo | Baicalein effectively reduces graft versus host disease induction without hindering T-cell homeostatic proliferation in mice, demonstrating its significant anti-inflammatory properties in vivo[2]. Further, in rats, baicalein administration guards against elevated heart to body weight ratios, increases in plasma brain natriuretic peptide levels, intraventricular septum thickness, and myocardial collagen volume in the left ventricle (all P<0.05, respectively). Its antifibrotic action is underscored by the reduced expression of pro-collagens I and III in the left ventricle, alongside diminished expression of 12-lipoxygenase, and lowered expression and activity of matrix metallopeptidase 9 and extracellular signal-regulated kinases, thus demonstrating baicalein's capability to inhibit cardiac fibrosis in hypertensive rats[4]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (185.02 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1.35 mg/mL (5 mM), Solution. |
| Keywords | XO | XanthineOxidase | Xanthine Oxidase | Inhibitor | inhibit | InfluenzaVirus | Influenza Virus | Ferroptosis | Baicalein |
| Inhibitors Related | Allopurinol | Rosiglitazone | L-Glutamic acid | Sorafenib | Curcumin | Gallic Acid Monohydrate | Inosine | L-Cystine | L-Glutamine | Naringenin | Crystal Violet | Cisplatin |
| Related Compound Libraries | Bioactive Compound Library | Anti-Cancer Clinical Compound Library | Anti-Viral Compound Library | Natural Product Library | Miao medicine Compound Library | Bitter Compound library | Cosmetic Ingredient Compound Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library | Anti-Cancer Active Compound Library | Food as Medicine Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $0.00/1kg |
VIP1Y
|
Shaanxi Xianhe Biotech Co., Ltd
|
2025-04-25 | |
| $0.00/25KG |
VIP5Y
|
Hebei Mujin Biotechnology Co.,Ltd
|
2024-10-11 | |
| $10.50/1KG |
VIP4Y
|
Hebei Chuanghai Biotechnology Co,.LTD
|
2024-08-21 | |
| $0.00/25kg |
Hebei Mujin Biotechnology Co.,Ltd
|
2024-08-05 | ||
| $1.00/1KG |
VIP6Y
|
Shaanxi Dideu Medichem Co. Ltd
|
2024-07-17 | |
| $65.00/1kg |
Hebei Zhuanglai Chemical Trading Co.,Ltd
|
2024-06-07 | ||
| $0.00/1kg |
VIP3Y
|
Hebei Kingfiner Technology Development Co.Ltd
|
2024-05-07 | |
| $0.00/1kg |
VIP2Y
|
BINBO BIOLOGICAL CO.,LTD
|
2024-04-23 | |
| $100.00/1bag |
Hebei Fengqiang Trading Co., LTD
|
2023-08-22 | ||
| $0.00/20kg |
VIP2Y
|
Wuhan Haorong Biotechnology Co.,Ltd
|
2023-08-15 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
INQUIRY