BACE1/2-IN-1 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-31 |
Product Details
| Product Name: BACE1/2-IN-1 | CAS No.: 2671036-34-1 |
| Supply Ability: 10g | Release date: 2025/07/31 |
Product Introduction
Bioactivity
| Name | BACE1/2-IN-1 |
| Description | BACE1/2-IN-1 (compound 34) is an effective BACE1 and BACE2 inhibitor with IC50 values of 0.01 and 0.0053 μM, respectively. It exhibits a lower Pgp efflux ratio, improved passive permeability, and decreased metabolic stability in liver microsomes. |
| In vitro | Compound 34, identified as BACE1/2-IN-1, exhibits a modest preference for BACE2 over BACE1, while maintaining a selectivity greater than 3000-fold when compared to Cathepsin D [1]. |
| In vivo | Administered subcutaneously at doses of 0-100 mg/kg in PDAPP (V717F) transgenic mice, BACE1/2-IN-1 (compound 34) significantly reduces cortical Aβ levels by 40% at 100 mg/kg and 24% at 30 mg/kg, with no significant reduction (12%NS) observed at 10 mg/kg [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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