Avagacestat NEW
| Price | $57 | $123 | $208 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-26 |
Product Details
| Product Name: Avagacestat | CAS No.: 1146699-66-2 |
| Purity: 99.77% | Supply Ability: 10g |
| Release date: 2025/07/26 |
Product Introduction
Bioactivity
| Name | Avagacestat |
| Description | Avagacestat (BMS-708163) (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, demonstrating a 193-fold selectivity against Notch. Phase 2. |
| Cell Research | BMS-708163 is dissolved in DMSO. The cell viability is assessed using a tetrazolium salt (WST-8)-based colorimetric assay from the Cell Counting Kit 8 (CCK-8). The cells are seeded into 96-well plates at an initial density of 5×103 cells/well and cultured for 24?h, after which the cells are cultured with DMSO, increased concentrations of gefitinib or BMS708163, BIBW2992, or the combination of BMS708163 and BIBW2992 for an additional 48?h. The A450 is measured in a microplate reader after 10?μL of CCK-8 solution is added and incubated for 1?h. The percentage of growth is shown relative to untreated controls. |
| In vitro | BMS-708163 exhibits weaker selectivity for inhibition of Notch processing with 193-fold IC50 value. [1] |
| In vivo | Oral administration of BMS-708163 significantly reduces Aβ40 levels for sustained periods in brain, plasma, and cerebrospinal fluid in rats and dogs. BMS-708163 has no dose-limiting effects in dogs (3 mg/kg during 6 months), with a high brain to plasma ratio (2.4). [1] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : < 1 mg/mL (insoluble or slightly soluble) Ethanol : < 1 mg/mL (insoluble or slightly soluble) DMSO : 96 mg/mL (184.3 mM), Sonication is recommended. |
| Keywords | γ-secretase | γ secretase(Aβ42) | γ secretase(Aβ40) | Notch | Inhibitor | inhibit | Gammasecretase | Gamma secretase | BMS708163 | BMS 708163 | Avagacestat |
| Inhibitors Related | Valproic acid sodium salt | Aβ42-IN-2 | Tangeretin | gamma-secretase modulator 1 | FLI-06 | Valproic Acid | CB-103 | Gossypolone | IMR-1A | Carvacrol | RO7185876 | DAPT |
| Related Compound Libraries | Failed Clinical Trials Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Cancer Cell Differentiation Compound Library | Hematonosis Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $200.00/1kg |
Hebei Mingeng Biotechnology Co., Ltd
|
2022-11-27 | ||
| $6.68/1KG |
VIP6Y
|
Career Henan Chemical Co
|
2020-01-10 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
INQUIRY