Atuveciclib S-Enantiomer NEW
| Price | $2258 | Get Latest Price | Get Latest Price |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-27 |
Product Details
| Product Name: Atuveciclib S-Enantiomer | CAS No.: 2250279-81-1 |
| Supply Ability: 10g | Release date: 2025/07/27 |
Product Introduction
Bioactivity
| Name | Atuveciclib S-Enantiomer |
| Description | Atuveciclib S-Enantiomer (BAY-1143572 S-Enantiomer) is a potent and selective CDK9 inhibitor, inhibiting CDK9/CycT1 with an IC50 of 16 nM. |
| In vitro | Atuveciclib (BAY-1143572) S-Enantiomer reveals very similar in vitro properties compared with Atuveciclib (BAY-1143572), well within the limits of measurement accuracy. However, with multiple batches of Atuveciclib (BAY-1143572) S-Enantiomer, there is a trend toward a slightly lower activity against CDK9 in the biochemical assay (IC 50 CDK9/CycT1: 16 nM) and antiproliferative activity against HeLa cells (IC 50 : 1100 nM) [1]. |
| In vivo | Atuveciclib (BAY-1143572) S-Enantiomer shows blood/plasma ratios close to 1, indicating similar distribution. It has comparable pharmacokinetic properties to its parent compound in rats, with a clearance rate (CL b) of 1.2 L/kg per hour, a steady-state volume of distribution (V ss) of 1.2 L/kg, a half-life (t 1/2) of 0.6 hours, and a bioavailability (F) of 53% [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 113 mg/mL (291.67 mM), Sonication is recommended. |
| Keywords | CDK9/CycT1 | Atuveciclib S-Enantiomer | Atuveciclib SEnantiomer | Atuveciclib S Enantiomer |
| Inhibitors Related | Ribociclib | Ro-3306 | Abemaciclib | Rafoxanide | AT7519 | Palbociclib monohydrochloride | CASIN | Palbociclib | GW 441756 | Sodium Oxamate | Dinaciclib | Abemaciclib methanesulfonate |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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