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Postion:Product Catalog >Atipamezole
Atipamezole
  • Atipamezole

Atipamezole NEW

Price $48 $68 $143
Package 5mg 10mg 25mg
Min. Order:
Supply Ability: 10g
Update Time: 2025-07-13

Product Details

Product Name: Atipamezole CAS No.: 104054-27-5
Purity: 99.76% Supply Ability: 10g
Release date: 2025/07/13

Product Introduction

Bioactivity

NameAtipamezole
DescriptionAtipamezole (Antisedan) is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug.
In vitroThe affinity of atipamezole for α2-adrenoceptors and its α2/α1 selectivity ratio are considerably higher than yohimbine. Atipamezole is not selective for subtypes of α2-adrenoceptors. It has negligible affinity for 5-HT1, 5-HT2 and I2 bindings sites[1].
In vivoAtipamezole is well-tolerated in rodents and exhibits modest cardiovascular effects (0.01–1 mg/kg, i.v.) in anesthetized, normotensive rats. It is frequently used by veterinarians to reverse sedation or anesthesia in animals. Atipamezole enhances sexual activity in rats and monkeys and increases pain-related responses in animals with sustained nociception by blocking noradrenergic feedback inhibition of pain. At low doses, it improves alertness, selective attention, planning, learning, and recall in experimental animals, although not necessarily affecting short-term working memory[1].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 39 mg/mL (183.71 mM), Sonication is recommended.
Ethanol : 39 mg/mL (183.71 mM), Sonication is recommended.
H2O : < 1 mg/mL (insoluble or slightly soluble)
Keywordsα2-adrenoceptor | MPV-1248 | MPV1248 | Inhibitor | inhibit | Beta Receptor | Atipamezole | AdrenergicReceptor | Adrenergic Receptor
Inhibitors RelatedOlanzapine | Mirtazapine | Octopamine hydrochloride | Gemfibrozil | Buflomedil hydrochloride | Dexmedetomidine hydrochloride | Phenylephrine hydrochloride | Amitriptyline hydrochloride | Isoprenaline hydrochloride | Trazodone hydrochloride | Mianserin hydrochloride | Doxepin hydrochloride
Related Compound LibrariesFailed Clinical Trials Compound Library | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | ReFRAME Related Library | Anti-Cancer Clinical Compound Library | Neurotransmitter Receptor Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Drug Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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