Atg4B-IN-2 NEW
| Price | $98 | $228 | $380 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-20 |
Product Details
| Product Name: Atg4B-IN-2 | CAS No.: 2765008-88-4 |
| Purity: 98.86% | Supply Ability: 10g |
| Release date: 2025/07/20 |
Product Introduction
Bioactivity
| Name | Atg4B-IN-2 |
| Description | Atg4B-IN-2. A potent, selective Atg4B inhibitor with anticancer activity, inhibits both Atg4B and PLA2, enabling autophagy that counteracts the anticancer activity of anti-desiccation-resistant prostate cancer drugs. |
| In vitro | In a dose-dependent manner, Atg4B-IN-2 (compound 21f) (1-10 μM; 2 hours) restores p62 expression in cells treated with amino acid-free (AF) conditions [1]. At concentrations of 1 and 5 μM (2 hours), Atg4B-IN-2 moderately decreases autophagic vesicles at 1 μM and almost completely inhibits autophagy at 5 μM [1]. At a concentration of 5 μM (2 hours), Atg4B-IN-2 inhibits Abi-induced autophagy, significantly enhances apoptotic cell death, and increases sensitivity to Abi [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 80 mg/mL (242.09 mM), Sonication is recommended. |
| Keywords | PLA2 | Autophagy | ATG4B |
| Inhibitors Related | Neomycin sulfate | Stavudine | Cysteamine hydrochloride | Sodium 4-phenylbutyrate | Hydroxychloroquine | Guanidine hydrochloride | Taurine | Valproic Acid | Paeonol | Naringin | Alginic acid | Gefitinib |
| Related Compound Libraries | Bioactive Compound Library | Autophagy Compound Library | Inhibitor Library | Anti-Prostate Cancer Compound Library | Metabolism Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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