Arzoxifene hydrochloride NEW
| Price | $2120 | $2780 | $3700 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-16 |
Product Details
| Product Name: Arzoxifene hydrochloride | CAS No.: 182133-27-3 |
| Supply Ability: 10g | Release date: 2025/07/16 |
Product Introduction
Bioactivity
| Name | Arzoxifene hydrochloride |
| Description | Arzoxifene hydrochloride is a selective estrogen receptor modulator that is a potent estrogen antagonist in mammary and uterine tissue. |
| In vitro | Arzoxifene inhibits cell growth as effectively as the antiestrogen tamoxifen, demonstrating statistically significant inhibition of pS2 and progesterone receptor B mRNA expression along with a significant agonistic effect on antitrypsin mRNA expression. Unlike estradiol and tamoxifen, arzoxifene does not upregulate cathepsin D mRNA and protein expression. |
| In vivo | Arzoxifene counteracts the ovariectomy-induced increase in body weight and serum cholesterol in treated rats, effectively reducing them below sham levels in a dose-dependent manner, with maximum efficacy comparable to estrogen or raloxifene. It prevents bone loss due to ovariectomy, showing maximal efficacy at 0.1-1 mg/kg/day [ED50: approximately 0.01 mg/kg]. Additionally, arzoxifene mitigates the estrogen-induced rise in uterine weight to vehicle-dosed control levels [ED50: 0.03 mg/kg/day]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | SERM-3 | SERM3 | Estrogen receptor | Arzoxifene hydrochloride | Arzoxifene Hydrochloride |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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