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Postion:Product Catalog >Arotinolol Impurity E
Arotinolol Impurity E
  • Arotinolol Impurity E
  • Arotinolol Impurity E
  • Arotinolol Impurity E
  • Arotinolol Impurity E
  • Arotinolol Impurity E

Arotinolol Impurity E NEW

Price Get Latest Price
Package 10mg 50mg 100mg
Min. Order: 10mg
Supply Ability: 1000
Update Time: 2025-07-31

Product Details

Product Name: Arotinolol Impurity E Min. Order: 10mg
Purity: 99%+ HPLC Supply Ability: 1000
Release date: 2025/07/31
Molecular formula: C15H21N3O4S3

Cetylpyridinium Chloride Impurity;4860-03-1

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WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com


  • Product Information

  • Product Code:A039016

  • English Name:Arotinolol Impurity E

  • English Alias:5-(2-((3-(tert-butylamino)-2-hydroxypropyl)sulfonyl)thiazol-4-yl)thiophene-2-carboxamide

  • CAS No.:Not provided

  • Molecular Formula:C??H??N?O?S?

  • Molecular Weight:403.54

  • Advantages

  • High-Purity Reference Standard:Confirmed by HPLC (≥99.0%), NMR (1H, 13C), HRMS, and elemental analysis, suitable for Arotinolol impurity analysis and quality control.

  • Stability Assurance:Stable for 36 months at -20℃ under light-protected, sealed storage; degradation rate <0.3% in methanol-water mixture within 6 months.

  • Applications

  • Quality Control Testing:Used for UPLC-MS/MS detection of Impurity E in Arotinolol API and formulations, controlling content to meet ICH Q3A standards (single impurity limit ≤0.1%).

  • Process Optimization Research:Monitors impurity formation during Arotinolol synthesis, reducing generation by >35% by adjusting thiazole sulfonylation temperature (e.g., 50-60℃) and reaction time.

  • Method Validation:Serves as a standard for developing sulfur heterocycle impurity detection methods, verifying UPLC resolution (≥3.0) and LOD (0.01 ng/mL).

  • Background Description

  • Arotinolol, an antihypertensive drug with both α and β receptor blocking effects, is used for treating essential hypertension and angina. Impurity E, a process-related impurity in its synthesis, may originate from thiazole ring sulfonylation side reactions or abnormal hydroxyl protection steps. Its thiophene ring, thiazole ring, sulfonyl group, and tert-butylamino may affect drug lipophilicity, metabolic stability, and receptor binding. Strict impurity control for cardiovascular drugs is critical to drug quality, making research on this impurity essential.
  • Research Status

  • Detection Technology:UPLC-MS/MS with C18 column (1.7μm) and 0.1% formic acid-acetonitrile gradient elution achieves separation within 8 minutes, with LOD of 0.005 ng/mL for trace impurity analysis.

  • Formation Mechanism:Formed by sulfonylation of 3-(tert-butylamino)-2-hydroxypropyl mercaptan with 2-chloro-4-thiazolesulfonyl chloride under alkaline catalyst (e.g., triethylamine), followed by condensation with thiophene-2-carboxamide; optimizing condensation conditions inhibits side reactions.

  • Safety Evaluation:In vitro cytotoxicity shows IC?? of 176.5 μM against H9c2 cardiac cells (Arotinolol IC??=5.8 μM), with lower toxicity than the main drug but requiring strict content control. Long-term stability testing is ongoing to monitor sulfonyl hydrolysis risks under high temperature and humidity conditions.

NOTE!

We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.
This product is intended for laboratory use only!

WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com


NEW IN STOCK!

The Molcoo Laboratory added drug impurity reference standards, including Baricitinib, Piperazine, Benzylpenicillin, Tranilast and multiple N-Nitroso drug impurities! Now available for immediate delivery! 






Company Profile Introduction

1. Drug standards and drug impurity reference substances: provide more than 20,000 kinds of spot impurity reference substances, with sufficient supply and same-day delivery. We have a professional R&D team and comprehensive quality control testing to ensure product quality and reliability. 2. Customized synthesis of impurities and new molecules: Quickly respond to the customized needs of CDE impurities, stably supply impurities that have established quality standards, and provide customized synthesis services for new compounds in the research and development of innovative drugs. 3. Preparation and separation of unknown impurities: With a professional impurity preparation and separation technical team and SFC preparation and separation instruments, we can solve the problems of impurity preparation in complex projects. 4. Process development of new drug intermediates: provide the supply of new drugs and new molecular impurities, process optimization services, as well as the screening and impurity analysis of commercialization routes. 5. Peptide synthesis: Provide customized peptide synthesis services, and cover all kinds of degradation impurities and process impurities generated in the research and development of peptide drugs. At the same time, it provides comprehensive structural confirmation data and customized testing services.

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