Ardisiacrispin A NEW
| Price | $83 | $197 | $290 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-06-28 |
Product Details
| Product Name: Ardisiacrispin A | CAS No.: 23643-61-0 |
| Purity: 99.43% | Supply Ability: 10g |
| Release date: 2025/06/28 |
Product Introduction
Bioactivity
| Name | Ardisiacrispin A |
| Description | Ardisiacrispin A (Deglucocyclamin) has cytotoxic activity toward HepG2 cancer cell with the GI(50) value of 1.56μM, it could inhibit the proliferation of Bel-7402 cells by inducing apoptosis and disassembling microtubule.Ardisiacrispin(A+B) exhibit prominent abilities to inhibit the proliferation of HL-60 cells by blocking the cell cycle at S phase and inducing apoptosis. |
| In vitro | Ardisiacrispin A+Ardisiacrispin B is a mixture of Ardisiacrispin A and ardisiacrispin B, derived from Ardisia crenata with a fixed proportion (2:1). METHODS AND RESULTS:The present study was conducted to investigate its anticancer activity on human cancer cells and its underlying mechanism of action. The (IC50)s of Ardisiacrispin A+Ardisiacrispin B on proliferation of several human cancer cell lines were in the range of 0.9-6.5 microg/ml by sulphorhodamine B-based colorimetric assay, in which Bel-7402 was the most sensitive cell line. Moreover, Ardisiacrispin A+Ardisiacrispin B induced dose-dependent apoptosis in Bel-7402 cells at doses of 1-10 microg/ml by flow cytometry, and resulted in the changes of the mitochondrial membrane depolarization, membrane permeability enhancement, and nuclear condensation in a dose-dependent manner through high-content screening analysis. Furthermore, Ardisiacrispin A+Ardisiacrispin B could disassemble microtubule in Bel-7402 cells; the fluorescence intensity of microtubules decreased at the concentration of 5-20 microg/ml. CONCLUSIONS: These findings suggest that Ardisiacrispin A+Ardisiacrispin B could inhibit the proliferation of Bel-7402 cells by inducing apoptosis and disassembling microtubule. |
| Storage | keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 10.61 mg/mL (10 mM), Sonication is recommended. |
| Keywords | LTS4 | LTS 4 | Inhibitor | inhibit | HSV | Ardisiacrispin A |
| Inhibitors Related | Floxuridine | Docusate sodium | Octyl gallate | Oxytetracycline Hydrochloride | 2-Deoxy-D-glucose | S-Methylisothiourea sulfate | Oxyresveratrol | Idoxuridine | Cytarabine | Acyclovir | Trigonelline chloride | Ganciclovir |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Terpene Natural Product Library | Traditional Chinese Medicine Monomer Library | Bioactive Compound Library | Selected Plant-Sourced Compound Library | Anti-Viral Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library | Natural Product Library for HTS | Bioactive Compounds Library Max | Anti-virus Traditional Chinese Medicine Monomer Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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